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製品番号: HY-182734

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BMS-357075

BMS-357075 is a pan-CDK inhibitor with CDK1 IC₅₀ 18 nM, CDK2 IC₅₀ 3 nM, CDK4 IC₅₀ 26 nM. BMS-357075 induces cytotoxicity in human ovarian cancer A2780 cells. BMS-357075 exhibits anticancer activity in mice against P388 murine leukemia. BMS-357075 can be used for the research of leukemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 350509-99-8
分子式: C₂₂H₃₁N₅O₂S₂
分子量:461.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-357075 構造式

CAS 番号: 350509-99-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

CDK1/cyclinB1

18 nM (IC₅₀)

CDK2/cyclinE

3 nM (IC₅₀)

CDK4/cyclin D

26 nM (IC₅₀)

CDK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	3 nM Compound: 19	Cytotoxic effect on human ovarian (A2780) cancer cell line Cytotoxic effect on human ovarian (A2780) cancer cell line	[PMID: 15125971]

体外実験

BMS-357075 (compound 19) potently inhibits CDK1/cyclin B (IC₅₀ = 18 nM), CDK2/cyclin E (IC₅₀ = 3 nM), and CDK4/cyclin D (IC₅₀ = 26 nM) in cell-free enzyme assays^[1].
BMS-357075 potently inhibits the viability of human ovarian cancer A2780 cells with an IC₅₀ of 3 nM^[1].
BMS-357075 shows 90% protein binding in mouse serum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

BMS-357075 (compound 19) (4 mg/kg; i.p.; once daily; 7 days) produces a 56% increase in survival time (%T/C = 156) against P388 murine leukemia in immunocompetent mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 350509-99-8
分子量 461.64
分子式 C₂₂H₃₁N₅O₂S₂
SMILES

OCC(C)(CNCC1=CN=C(NC2=NC=C(SCC3=NC=C(C(C)(C)C)O3)S2)C=C1)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Misra RN, et al. Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg Med Chem Lett. 2004;14(11):2973-2977. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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