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Calcimycin

(別名: A-23187; Antibiotic A-23187)
26 Cited Publications
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Based on 26 publication(s) in Google Scholar

Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy.

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  • 純度: 99.10%
  • CAS 番号: 52665-69-7
  • 分子式: C29H37N3O6
  • 分子量:523.62
  • 保管条件:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

  • Calcimycin Chemical Structure
    Calcimycin 構造式
  • Experimental Validation Results for Calcimycin
  • Experimental Validation Results for Calcimycin
  • Experimental Validation Results for Calcimycin
  • Experimental Validation Results for Calcimycin
  • Experimental Validation Results for Calcimycin
CAS 番号: 52665-69-7
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  • Calcimycin Chemical Structure
    Calcimycin Chemical Structure
    1/16
  • 1/16

    Calcimycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 20:e11873. [Abstract]

    Customer Validation
     A23187 (5 µM; 1–6 h) induced apoptosis in microglia in vitro. Microglia viability was assessed using the CCK-8 assay.

  • 1/16

    Calcimycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 20:e11873. [Abstract]

    Customer Validation
     A23187 (5 µM; 4 h). Representative images of microglia stained with Iba1, citH3, and MPO triple staining, and colocalization analysis of MPO, citH3, and DNA in the three cell groups.

  • 1/16

    Calcimycin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

    Customer Validation
     Cells were treated with different concentrations of Calcimycin (A23187: 2 µmol/L, 4 µmol/L, 8 µmol/L, 10 µmol/L; 24 h), and the effect of A23187 on STAT1 expression was assessed by Western blotting.

  • 1/16

    Calcimycin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

    Customer Validation
     Cells were treated with A23187 (4 µmol/L; 24 h) to examine the effect of A21187 on the binding ability of TRIM21 and STAT1 by Co‐IP and western blotting, and the result showed that A23187 reversed the dissociation of TRIM21 and STAT1 in the context of TGM2 and increased ubiquitination of STAT1.

  • 1/16

    Calcimycin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

    Customer Validation
     The effect of A23187 (4 µmol/L; 0-96 h) and ZM39923 (20 nmol/L) on GC cell proliferation was evaluated by CCK8 assay. The result showed that ZM39923 promoted cell proliferation while A23187 had an inhibitory role in GC cell proliferation.

  • Calcimycin