Cernuumolide J
Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC50 value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2019163-02-9
- 分子式: C24H34O8
- 分子量:450.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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JNK3 |
Stat-3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
18.36 μM
Compound: 10
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27668963] |
| A549 | IC50 |
4.7 μM
Compound: 20
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Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
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[PMID: 30869892] |
| BEL-7404 tumor cell line | IC50 |
7.35 μM
Compound: 10
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Cytotoxicity against human Bel7404 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Bel7404 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27668963] |
| HCT-116 | IC50 |
5.51 μM
Compound: 10
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27668963] |
| HL-60 | IC50 |
3 μM
Compound: 20
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Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
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[PMID: 30869892] |
| MDA-MB-231 | IC50 |
7.53 μM
Compound: 10
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 27668963] |
化学情報
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CAS 番号 2019163-02-9
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分子量 450.52
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分子式 C24H34O8
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SMILES
CC(C)C(O[C@@H]1[C@]2([H])[C@@](C(C(O2)=O)=C)([H])[C@@H](C([C@@H](CCC[C@@]1(O)C)C)=O)OC(/C(C)=C\C)=O)=O
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別名
TMJ-105
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cernuumolide J 関連分類
HY-N13294 関連分類
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