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Dalpiciclib isethionate

(別名: SHR-6390 isethionate)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Dalpiciclib (isethionate) is a CDK4/6 inhibitor. Dalpiciclib (isethionate) inhibits the kinase activity of CDK4 and CDK6, thereby blocking the G1-to-S phase transition of the cell cycle and suppressing abnormal cell proliferation. Dalpiciclib (isethionate) can be used for the study of breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • CAS 番号: 1980822-14-7
  • 分子式: C27H36N6O6S
  • 分子量:572.68
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Dalpiciclib isethionate Chemical Structure
    Dalpiciclib isethionate 構造式
  • Experimental Validation Results for Dalpiciclib isethionate
  • Experimental Validation Results for Dalpiciclib isethionate
  • Experimental Validation Results for Dalpiciclib isethionate
  • Experimental Validation Results for Dalpiciclib isethionate
  • Experimental Validation Results for Dalpiciclib isethionate
  • Experimental Validation Results for Dalpiciclib isethionate
  • Experimental Validation Results for Dalpiciclib isethionate
CAS 番号: 1980822-14-7
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Cell Proliferation/Viability AssayCell Imaging/StainingIFFlow CytometryWBCell Migration/Invasion AssayIn Vivo Imaging
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  • Dalpiciclib isethionate Chemical Structure
    Dalpiciclib isethionate Chemical Structure
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    Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]

    Customer Validation
     22Rv1 and C4-2B cells were treated for 48 h with ENZ and DAL in a fixed-ratio combination (10:1), with 2-fold serial dilutions of ENZ (10–160 μM) and Dalpiciclib (DAL) (1–16 μM).

  • 1/16

    Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]

    Customer Validation
     Representative images of colony formation assays in 22Rv1 and C4-2B cells treated with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination for 12–17 days.

  • 1/16

    Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]

    Customer Validation
     Representative immunofluorescence images of BrdU incorporation assays in 22Rv1 and C4-2B cells treated with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination for 48 h.

  • 1/16

    Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]

    Customer Validation
     Representative Annexin V/PI flow cytometry plots showing apoptosis in 22Rv1 and C4-2B cells after 48-hour treatment with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination.

  • 1/16

    Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]

    Customer Validation
     Western blot analysis of cell cycle-related proteins in 22Rv1 and C4-2B cells treated with or without ENZ (35 μM) and/or Dalpiciclib (DAL) (2 μM) for 48 h.

  • 1/16

    Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]

    Customer Validation
     Representative images of wound-healing assays conducted on 22Rv1 and C4-2B cells treated with DMSO, ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or ENZ (35 μM) + DAL (2 μM) for 24 h.

  • 1/16

    Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]

    Customer Validation
     Bioluminescence imaging and representative photographs of excised popliteal lymph nodes from nude mice at the experimental endpoint (day 28) treated with Dalpiciclib (DAL) (75 mg/kg, i.g.).

  • Dalpiciclib isethionate