DBr-1
Based on 1 Customer Validation
DBr-1 is a potent BRD9 PROTAC degrader (KD: 13 nM). DBr-1 can overcome intrinsic resistance to VHL-degrader. Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BRD9/BRD7 bromodomains inhibitor (HY-100352).
(Pink: BRD9 ligand (HY-100352); Blue: Cereblon ligand (HY-149934); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.87%
- 分子式: C55H68ClN9O5
- 分子量:970.64
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
化学情報
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性状 Solid
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分子量 970.64
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分子式 C55H68ClN9O5
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Color Off-white to light yellow
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SMILES
COC1=C(C(C2=C3C=NC=C2)=CN(C)C3=O)C=C(OC)C(CN4CCC(OCCCCCC(N5CCN(C6=CC=C7C(N=C(C8(C9=CC=C(Cl)C=C9)CCCCC8)N=C7NCCN)=C6)CC5)=O)CC4)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (103.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0302 mL | 5.1512 mL | 10.3025 mL | 25.7562 mL |
| 5 mM | 0.2060 mL | 1.0302 mL | 2.0605 mL | 5.1512 mL | |
| 10 mM | 0.1030 mL | 0.5151 mL | 1.0302 mL | 2.5756 mL | |
| 15 mM | 0.0687 mL | 0.3434 mL | 0.6868 mL | 1.7171 mL | |
| 20 mM | 0.0515 mL | 0.2576 mL | 0.5151 mL | 1.2878 mL | |
| 25 mM | 0.0412 mL | 0.2060 mL | 0.4121 mL | 1.0302 mL | |
| 30 mM | 0.0343 mL | 0.1717 mL | 0.3434 mL | 0.8585 mL | |
| 40 mM | 0.0258 mL | 0.1288 mL | 0.2576 mL | 0.6439 mL | |
| 50 mM | 0.0206 mL | 0.1030 mL | 0.2060 mL | 0.5151 mL | |
| 60 mM | 0.0172 mL | 0.0859 mL | 0.1717 mL | 0.4293 mL | |
| 80 mM | 0.0129 mL | 0.0644 mL | 0.1288 mL | 0.3220 mL | |
| 100 mM | 0.0103 mL | 0.0515 mL | 0.1030 mL | 0.2576 mL |
DBr-1 関連分類
HY-156744 関連分類
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