F81-1144b
F81-1144b is a MMP-1 and MMP-3 inhibitor with IC50 values of 5 nM and 29 nM, respectively. F81-1144b reduces serum and hepatic triacylglycerol levels, decreases the secretion of very-low-density lipoprotein-triacylglycerol, inhibits de novo hepatic fatty acid synthesis, and lowers serum insulin and glucose levels. F81-1144b can be used for the research of hypertriglyceridemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 306733-22-2
- 分子式: C27H37N3O5
- 分子量:483.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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MMP-1 5 nM (IC50) |
MMP-3 27 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (7-week-old male; high-sucrose diet-induced hypertriglyceridemia)[1]
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Dosage:50 mg/kg; 100 mg/kg
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Administration:s.c.; once daily; 7 days
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Result:Reduced serum TAG levels in a dose-dependent manner, with 100 mg/kg restoring levels to normal diet-fed control values.
Reduced serum cholesterol levels in a dose-dependent manner, with 100 mg/kg restoring levels to normal diet-fed control values.
Returned slightly elevated serum glucose levels to normal values at both 50 mg/kg and 100 mg/kg.
Markedly reduced HSD-elevated serum insulin levels.
Significantly reduced hepatic TAG levels in a dose-dependent manner; did not significantly change hepatic phospholipid levels.
Significantly suppressed hepatic de novo fatty acid synthesis at 100 mg/kg.
Significantly decreased HSD-elevated microsomal glycerol-3-phosphate acyltransferase (GPAT) activity at 100 mg/kg.
Upregulated hepatic gene expression of Lpl, Cd36, Apoa1, Ucp2 in a dose-dependent manner.
化学情報
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CAS 番号 306733-22-2
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分子量 483.60
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分子式 C27H37N3O5
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SMILES
O=C([C@H](CC1=CC=C(C=C1)CN)NC([C@@H]([C@H](CCCC2=CC=CC=C2)C(NO)=O)CC(C)C)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
F81-1144b 関連分類
HY-125507 関連分類
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