GPLGVRG
GPLGVRG is an MMP13-responsive linker peptide. GPLGVRG can be hydrolyzed by MMP13, which in turn triggers micellar disintegration, loss of amphipathicity, and increases the chondrocyte uptake rate of the related delivery system. GPLGVRG can be used in the research of osteoarthritis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 915404-04-5
- 分子式: C28H50N10O8
- 分子量:654.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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MMP13 |
The GPLGVRG peptide is selectively cleaved by MMP13 present in IL-1β-stimulated osteoarthritis (OA) chondrocytes, generating a detectable fluorescent signal via FRET substrate cleavage, and this signal is inhibitable by MMP inhibitors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 12 weeks old, 300 to 350 g, ACLT+DMM induced knee OA)[1]
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Dosage:micelle:exosome protein mass ratio 10:1; 250 μM DHA
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Administration:intra-articular; single dose
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Result:Reduced Osteoarthritis Research Society International.
Preserved cartilage thickness.
Increased chondrocyte number.
Reduced positive staining for ADAMTS5 to 17.0% versus 79.3% in OA control.
Reduced positive staining for MMP13 to 14.7% versus 72.1% in OA control.
Increased trabecular bone mineral density to 1.4 versus 1.3 in OA control.
Increased trabecular thickness to 0.2 mm versus 0.1 mm in OA control.
Increased bone volume fraction to 45.2% versus 33.9% in OA control.
Penetrated ex vivo rat femoral head cartilage to 74.0 μm versus 32.4 μm for unmodified exosomes at 48 h.
Penetrated ex vivo rat femoral head cartilage to 155.0 μm versus 36.3 μm for unmodified exosomes at 72 h.
化学情報
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CAS 番号 915404-04-5
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分子量 654.76
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分子式 C28H50N10O8
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配列
Gly-Pro-Leu-Gly-Val-Arg-Gly
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シーケンスの短縮
GPLGVRG
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GPLGVRG 関連分類
HY-P11800 関連分類
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