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Grp94-IN-3

Grp94-IN-3 (Compound 47) is a selective ATP competitive inhibitor of Grp94, with a Kd value of 76 nM. Grp94-IN-3 has a much lower affinity for Hsp90α, with a Kd value of 9.17 μM. Grp94-IN-3 induces the degradation of integrin α2 (Integrin α2) in MDA-MB-231 cells and reduces the intracellular accumulation of mutant cardiac proteins in human trabecular meshwork cells. Grp94-IN-3 can be used for the study of metastatic cancer and open-angle glaucoma.

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  • 分子式: C22H24ClN3O4
  • 分子量:429.90
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Grp94-IN-3 Chemical Structure
    Grp94-IN-3 構造式
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  • Grp94-IN-3 Chemical Structure
    Grp94-IN-3 Chemical Structure
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  • Grp94-IN-3