Niazirin
Based on 1 Customer Validation
Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 122001-32-5
- 分子式: C14H17NO5
- 分子量:279.29
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PKCζ |
NOX4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>45 μM
Compound: 8
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated 30 mins prior to LPS challenge
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated 30 mins prior to LPS challenge
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[PMID: 20685125] |
Niazirin (2-64 μM; 24 h) dose-dependently inhibits high glucose-induced abnormal proliferation of porcine aortic VSMCs, with no effect on VSMCs under normal glucose conditions[1].
Niazirin (5-25 μM; 24 h) significantly reduces high glucose-induced ROS production in porcine aortic VSMCs[1].
Niazirin (5-25 μM; 48 h) reverses high glucose-induced oxidant-antioxidant imbalance in porcine aortic VSMCs by reducing MDA production and increasing T-AOC, GPx, and SOD levels[1].
Niazirin (5-25 μM) inhibits high glucose-induced activation of the PKCζ/Nox4 pathway in porcine aortic VSMCs by reducing PKCζ Thr410 phosphorylation and Nox4 protein expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:porcine aortic vascular smooth muscle cells (VSMCs) under normal glucose (NG) or high glucose (HG) conditions
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Concentration:2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM
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Incubation Time:24 h
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Result:Inhibited high glucose-induced VSMCs proliferation in a dose-dependent manner at all tested concentrations (p < 0.01).
Had no obvious effect on VSMCs growth under normal glucose conditions.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 20-25 g, diabetes induced by 8 weeks of high fat and carbohydrate diet followed by streptozotocin injection)[1]
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Dosage:10 mg/kg; 40 mg/kg
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Administration:i.g.; daily; 14 days
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Result:Significantly increased serum total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels relative to diabetic controls (p < 0.05 for T-AOC, GPx; p < 0.01 for SOD) at 10 mg/kg.
Significantly decreased serum malondialdehyde (MDA) production relative to diabetic controls (p < 0.01) at 10 mg/kg.
Significantly reduced thoracic aorta PKCζ Thr410 phosphorylation and Nox4 protein expression relative to diabetic controls (p < 0.05 for both) at 10 mg/kg.
Reduced aortic Ki67 positive area in diabetic controls.
Significantly increased serum T-AOC, SOD, and GPx levels relative to diabetic controls at 40 mg/kg.
Significantly decreased serum MDA production relative to diabetic controls (p < 0.01) at 40 mg/kg.
Significantly reduced thoracic aorta PKCζ Thr410 phosphorylation and Nox4 protein expression relative to diabetic controls (p < 0.01 for both) at 40 mg/kg.
化学情報
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CAS 番号 122001-32-5
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性状 Solid
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分子量 279.29
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分子式 C14H17NO5
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Color White to off-white
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SMILES
O[C@H]([C@@H]([C@H]1O)O)[C@@H](O[C@H]1C)OC(C=C2)=CC=C2CC#N
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Niazirin 関連分類
HY-N9097 関連分類
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