Oleocanthal
Based on 1 Customer Validation
Oleocanthal is an orally active phenolic seciridoid compound. Oleocanthal can be extracted from olive oil. Oleocanthal inhibits COX-1 and COX-2, reduces ROS and NO, and upregulates Nrf-2 and HO-1. Oleocanthal reduces Aβ deposition. Oleocanthal exhibits anti-Leishmania activity against promastigotes and amastigotes of L. major, with IC50 values of 18.7 and 87 μg/mL, respectively. Oleocanthal exhibits anticancer activity against colon, breast, liver, and melanoma cancers. Oleocanthal also exhibits anti-inflammatory and neuroprotective properties. Oleocanthal can be used in Alzheimer's disease research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.04%
- CAS 番号: 289030-99-5
- 分子式: C17H20O5
- 分子量:304.34
-
保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Parasite アイソフォーム固有の製品をすべて表示
More
生物活性
|
COX-1 |
COX-2 |
Leishmania |
HO-1 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
10 μM
Compound: 50
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 38733884] |
| MDA-MB-231 | IC50 |
15 μM
Compound: 1
|
Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
|
[PMID: 23403296] |
| MDA-MB-231 | IC50 |
7.5 μM
Compound: 1
|
Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound healing assay
Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound healing assay
|
[PMID: 23403296] |
| NCI-H322M | IC50 |
26.3 μM
Compound: 50
|
Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38733884] |
Oleocanthal (25-100 μM) reduces ROS, nitrites, and pro-inflammatory cytokines levels in LPS-stimulated murine peritoneal macrophages[1].
Oleocanthal (1-25 μM; 12 h) decreases LPS-induced NOS2 synthesis and NO production in ATDC-5 chondrocytes[2].
Oleocanthal (0-200 μg/mL; 48-60 h) inhibits the growth of L. major promastigotes and amastigotes, presenting IC50 values of 18.7 and 87 μg/mL, respectively[5].
Oleocanthal shows inhibitory activity against COX-1 and COX-2 enzymes[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:murine peritoneal macrophages
-
Concentration:25 μM, 50 μM, 100 μM
-
Incubation Time:30 min
-
Result:Upregulated protein expression of Nrf-2 (25 μM: 1.57; 50 μM: 1.54; 100 μM: 1.63) and HO-1 (25 μM: 2.12; 50 μM: 2.24; 100 μM: 1.92).
Oleocanthal (5 mg/kg b.w.; i.p.; 3 times/week; 16 total doses) suppresses footpad thickness, decreases parasite load, and induces Th1-type immunity in L. major-infected BALB/c mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male wild-type C57BL/6J and 5xFAD mice (4 and 9 months of age)[3]
-
Dosage:10 mg/kg
-
Administration:Oral gavage, daily, for 3 months
-
Result:Improved metabolic parameters (body weight, food and water intake, energy expenditure, etc.) and behavioral parameters (sleep patterns, anxiety-like behavior).
Reduced brain Aβ levels and IgG extravasation (improved BBB function).
Increased sleep hours and decreased movement related to anxiety-like behavior.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 289030-99-5
-
性状 Solid
-
分子量 304.34
-
分子式 C17H20O5
-
Color White to off-white
-
SMILES
C/C=C([C@H](CC(OCCC1=CC=C(C=C1)O)=O)CC=O)/C=O
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Montoya T, et al. Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways. J Agric Food Chem. 2019 May 15;67(19):5552-5559. [Content Brief]
[2]. Iacono A, et al. Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line. Arthritis Rheum. 2010 Jun;62(6):1675-82. [Content Brief]
[3]. Yang E, et al. Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer's Disease. Molecules. 2023 Jul 23;28(14):5592. [Content Brief]
[5]. Karampetsou K, et al. Exploring the Immunotherapeutic Potential of Oleocanthal against Murine Cutaneous Leishmaniasis. Planta Med. 2022 Aug;88(9-10):783-793. [Content Brief]
[6]. Costa V, et al. Anti-Inflammatory Activity of Olive Oil Polyphenols-The Role of Oleacein and Its Metabolites. Biomedicines. 2022 Nov 21;10(11):2990. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Oleocanthal 関連分類
HY-124481 関連分類
Powered by Bioz