製品番号: HY-N1435

Oroxin B

(別名: オロキシンB)

6 Cited Publications

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Oroxin B (OB) is a BBB-permeable flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT. Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells.

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純度: 99.39%
CAS 番号: 114482-86-9
分子式: C₂₇H₃₀O₁₅
分子量:594.52

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Oroxin B 構造式

CAS 番号: 114482-86-9

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PI3K アイソフォーム固有の製品をすべて表示 :

体外実験

Oroxin B (0-2 μM, 48 h) inhibits the proliferation (48 h), and induces apoptosis (12 h) of the human hepatoma cell line (SMMC 7721)^[1].
Oroxin B (0-2 μM, 48 h) increases PTEN and inhibits COX-2, VEGF, p-AKT, and PI3K in SMMC 7721^[1].
Oroxin B (0-30 μM, 48 h) selectively induces ER stressin (stress marker: glyburide labeled by rhodamine) in Raji cell^[2].
Oroxin B (160 μM, 24 h) inhibits IL-1β induced inflammation-related (iNOS, COX-2, TNF-α, IL-6, and IL-1β) markers in chondrocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:

Raji cells
Concentration:

0-40 μM
Incubation Time:

48 h
Result:

Decreased ER stress master genes (GRP78 and ATF6) mRNA level.

体内実験

Oroxin B (30 mg/kg, i.p., 28 days) induces malignant lymphoma cell ER stress, and inhibits tumor growth in human lymphoma cell (Raji cell) xenograft model^[2].
Oroxin B (160 μM of 10 μL, injected into the knee joints of mice) protects articular cartilage in destabilized medial meniscus (DMM) induced mice OA^[3].
Oroxin B (200 mg/kg/day, oral gavage) relieves hepatic inflammation and inhibits MAFLD progression in HFD-fed rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Human lymphoma cell (Raji cell) xenograft model^[2]
Dosage:

30 mg/kg
Administration:

i.p., 28 days
Result:

Induced malignant lymphoma cell ER stress.
Inhibited tumor growth.
Prolonged overall survival of tumor-bearing mice.

Animal Model:

HFD-fed rats^[4]
Dosage:

200 mg/kg/day
Administration:

oral gavage
Result:

Reduced the levels of plasma lipids, LPS, IL-6, and TNF-α.
Inhibited liver fibrosis by reducing collagen deposition.

化学情報

CAS 番号 114482-86-9
性状 Solid
分子量 594.52
分子式 C₂₇H₃₀O₁₅
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)O4)O)O)O)=C(O)C(O)=C13
別名

オロキシンB
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (6)

All Cell Migration/Invasion AssayCell Imaging/StainingWBIn Vivo Efficacy StudyHistological Imaging/Staining

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Journal Impact Factor

Autophagy

Chaperone-mediated autophagy reprograms heterogeneous subsets of activated macrophages in immune thrombocytopenia. [Abstract]

2026 Jun 26:1-17. PMID: 42329073
Asian J Pharm Sci

Enhancing HepG2 cell apoptosis with a combined nanoparticle delivery of miR-128-3p agomir and Oroxin B: A novel drug delivery approach based on PI3K-AKT and VEGF pathway crosstalk. [Abstract]

2025 Jun;20(3):100909. PMID: 40487120

Oroxin B purchased from MedChemExpress. Usage Cited in: Asian J Pharm Sci. 2025 Jun;20(3):100909. [Abstract]

Effects of NA-miR-128–3p and Oroxin B (OXB) (20 μM) on HepG2 cells examined by scratch wound healing assay.

Oroxin B purchased from MedChemExpress. Usage Cited in: Asian J Pharm Sci. 2025 Jun;20(3):100909. [Abstract]

Clone forming assay was carried out to evaluate proliferation of HepG2 cells. Cells (1000/well) were inoculated into complete medium within the 12-well plate until adherence treated with Oroxin B (OXB) (20 μM).

Oroxin B purchased from MedChemExpress. Usage Cited in: Asian J Pharm Sci. 2025 Jun;20(3):100909. [Abstract]

Co-treatment with NA-miR-128–3p and Oroxin B (OXB) (40 nM) attenuated the expression of AKT1 and VEGF1 in HepG2 cells.

Oroxin B purchased from MedChemExpress. Usage Cited in: Asian J Pharm Sci. 2025 Jun;20(3):100909. [Abstract]

Relative tumor volume treated with Oroxin B (OXB) (19.8 mM/kg, tail vein).

Oroxin B purchased from MedChemExpress. Usage Cited in: Asian J Pharm Sci. 2025 Jun;20(3):100909. [Abstract]

H&E staining in mouse tumor tissue treated with Oroxin B (OXB) (19.8 mM/kg, tail vein).
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 Oct 15:489:144992. PMID: 40466530
Mol Med Rep

Regulation of the PTEN/PI3K/AKT pathway in RCC using the active compounds of natural products in vitro. [Abstract]

2021 Nov;24(5):766. PMID: 34490473
Research Square Print

2022 Jun.

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (168.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6820 mL

8.4101 mL

16.8203 mL

5 mM

0.3364 mL

1.6820 mL

3.3641 mL

10 mM

0.1682 mL

0.8410 mL

1.6820 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (283 KB)
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- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
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MS (2659 KB)
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IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li NN, et al. Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer. Pharmacogn Mag. 2018 Apr-Jun;14(54):207-213. [Content Brief]

[2]. Yang P, et al. Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):269-79. [Content Brief]

[3]. Lu R, et al. Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy. Front Endocrinol (Lausanne). 2022 Dec 1;13:1060721. [Content Brief]

[4]. Huang Y, et al. Oroxin B improves metabolic-associated fatty liver disease by alleviating gut microbiota dysbiosis in a high-fat diet-induced rat model. Eur J Pharmacol. 2023 Jul 15;951:175788. [Content Brief]

[5]. Niu K, et al. Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LC-MS/MS assay. Biomed Chromatogr. 2019 Mar;33(3):e4417. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6820 mL	8.4101 mL	16.8203 mL	42.0507 mL
	5 mM	0.3364 mL	1.6820 mL	3.3641 mL	8.4101 mL
	10 mM	0.1682 mL	0.8410 mL	1.6820 mL	4.2051 mL
	15 mM	0.1121 mL	0.5607 mL	1.1214 mL	2.8034 mL
	20 mM	0.0841 mL	0.4205 mL	0.8410 mL	2.1025 mL
	25 mM	0.0673 mL	0.3364 mL	0.6728 mL	1.6820 mL
	30 mM	0.0561 mL	0.2803 mL	0.5607 mL	1.4017 mL
	40 mM	0.0421 mL	0.2103 mL	0.4205 mL	1.0513 mL
	50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.8410 mL
	60 mM	0.0280 mL	0.1402 mL	0.2803 mL	0.7008 mL
	80 mM	0.0210 mL	0.1051 mL	0.2103 mL	0.5256 mL
	100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.4205 mL

Keywords

Oroxin B

6 Cited Publications

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Oroxin B

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MedChemExpress（MCE）の使用を引用している文献 Oroxin B

PI3K アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (6)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Oroxin B 関連分類

HY-N1435 関連分類