SJY26
SJY26 is a PI3K/HDAC dual-target inhibitor with IC50s of 0.59 nM (PI3Kα and PI3Kδ), 2.02 nM (PI3Kγ), 12.69 nM (PI3Kβ) and 114 nM (HDAC1). SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis. SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation (Ac-H3). SJY26 can be used for the studies of non-small cell lung cancer and leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C35H26F2N6O5S
- 分子量:680.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Histone Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
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PI3Kα 0.59 nM (IC50) |
PI3Kδ 0.59 nM (IC50) |
PI3Kγ 2.02 nM (IC50) |
PI3Kβ 12.69 nM (IC50) |
HDAC1 114 nM (IC50) |
SJY26 (24 h) exhibits potent inhibitory activity against Jurkat, PC9R, MCF-7 and K562 cells with IC50s of 0.38 μM, 0.59 μM, 1.98 μM and 4.30 μM[1].
SJY26 (1.25-2.5 μM, 0-48 h) effectively inhibits the migration ability of PC9R cells in a concentration-dependent manner[1].
SJY26 (2.5 μM, 24 h) arrests PC9R cells in the G2/M phase, preventing them from entering mitosis and completing proliferation[1].
SJY26 (2.5-5 μM, 48 h) induces cell apoptosis in a concentration-dependent manner in PC9R cells[1].
SJY26 (2.5-5 μM, 24 h) down-regulates the PI3K-AKT signaling pathway while up-regulates the level of histone acetylation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC9R cells
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Concentration:1.25 μM and 2.5 μM
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Incubation Time:0, 24 and 48 h
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Result:Effectively inhibited the migration ability of PC9R cells in a concentration-dependent manner.
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Cell Line:PC9R cells
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Concentration:2.5 μM
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Incubation Time:24 h
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Result:Significantly increased the proportion of cells in the G2/M phase.
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Cell Line:PC9R cells
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Concentration:2.5 μM and 5 μM
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Incubation Time:48 h
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Result:Induced cell apoptosis in a concentration-dependent manner.
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Cell Line:PC9R cells
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Concentration:2.5 μM and 5 μM
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Incubation Time:24 h
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Result:Down-regulated the PI3K-AKT signaling pathway while up-regulated the level of histone acetylation.
化学情報
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分子量 680.68
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分子式 C35H26F2N6O5S
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SMILES
O=C(C1=CC=NC2=CC=C(C3=CC(NS(=O)(C4=CC=C(F)C=C4F)=O)=C(OC)N=C3)C=C12)NC5=CC=C(C(NC6=CC=CC=C6N)=O)C=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SJY26 関連分類
HY-178485 関連分類
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