YY173
YY173 is a dual inhibitor for CDK4 and CDK6 with IC50 of 7.7 and 88 nM. YY173 inhibits the proliferation of cell Jurkat with an IC50 of 1.46 μM. YY173 can be used for synthesis of PROTAC CDK4/6 degrader 1 (HY-163786).
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- CAS 番号: 330550-51-1
- 分子式: C21H25N7O
- 分子量:391.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CDK4 7.7 nM (IC50) |
CDK6 88 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
1.466 μM
Compound: YY173
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Anti-proliferative activity against human Jurkat cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay
Anti-proliferative activity against human Jurkat cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay
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[PMID: 38943626] |
化学情報
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CAS 番号 330550-51-1
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分子量 391.47
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分子式 C21H25N7O
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SMILES
O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCNCC4)=NC=C2N=C1)C5CCCC5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
YY173 関連分類
HY-163787 関連分類
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