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AG490

(Synonyms: Tyrphostin AG490; Tyrphostin B42)
165 Cited Publications
고객리뷰

Based on 165 publication(s) in Google Scholar

AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity: 99.86%
  • CAS No.: 133550-30-8
  • 화학식: C17H14N2O3
  • 분자량:294.30
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • AG490 Chemical Structure
    AG490 Chemical Structure
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
CAS No.: 133550-30-8
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  • AG490 Chemical Structure
    AG490 Chemical Structure
    1/16
  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Jun 13;10(6):465. [Abstract]

    Customer Validation
     pcDNA-AQP3 is used to upregulated AQP3 expression. We found AQP3 overexpression had no influence on STAT3 expression, but could promote STAT3 activation. AG-490 treatment could inhibit STAT3 activation and eliminate the influence of AQP3 overexpression.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2019 Mar 25:232:62-72. [Abstract]

    Customer Validation
     After incubation with AG490 (50 μM), RP (40 μg/mL) or both for 24 h, total protein from SMMC-7721s are analyzed by Western blot.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2019 Nov 1;7:253. [Abstract]

    Customer Validation
     STAT3 regulates miR-384 transcription. CD4C naïve T cells are cultured with IL-6, siRNA, or AG490, and then p-STAT3 and STAT3 levels are tested by Western blot.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 29;9(9):867. [Abstract]

    Customer Validation
     AG490 decreases c-Met expression in MGC803 and AGS cells when they are co-cultured with CAFs.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Nov 7;66(44):11757-11766. [Abstract]

    Customer Validation
     The number of GFP-LC3 dots are reduced significantly after inhibiting STAT3 (AG-490) signaling.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Reprod Biol Endocrinol. 2018 May 31;16(1):55. [Abstract]

    Customer Validation
     Western blot analysis of claudin 5, occludin and ZO-1 in TM4 cells, cells are treated with 100 nM Leptin or pre-treated with different inhibitors following a 100 nM Leptin treatment.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2018 Dec 26;12(3):485-492.  [Abstract]

    Customer Validation
     AG490 blocks the IL6/STAT3/PD-L1 signaling pathway and is more pronounced after knockdown of IDO1. T24 and UMUC3 cells after IDO1 knockdown are treated with STAT3 specific inhibitor AG490. The protein levels of STAT3, P-STAT3, and PD-L1 are measured by Western blot analysis.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2018 Jun;17(6):7595-7602. [Abstract]

    Customer Validation
     Representative images show the expression levels of α SMA, calponin and osteopontin (OPN) protein.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Reprod Sci. 2019 Jun;26(6):829-838. [Abstract]

    Customer Validation
     The protein expression levels of p-JAK2, JAK2, p-STAT3, and STAT3 are detected by Western blot with the treatment of ,MSA, AG490 or MSA+AG490.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Oncogene. 2017 May 25;36(21):2946-2956. [Abstract]

    Customer Validation
     (a) Immunoblotting analysis of pSTAT3, CITED4, and CCND1 in CL1-5 cells treated with AG490 (5 μM) for the indicated times. α-Tubulin is assessed as an internal control. (b) Q-PCR analysis of CITED4 in A549 cells treated with AG490 (5 μM) for the indicated times.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2017 Dec;16(6):9309-9316. [Abstract]

    Customer Validation
     Ad IL 23 intensifies the high expression levels of IL 17A, TNF α and IL 6 induced by myocardial I/R, which is inhibited by AG490. Levels of IL 17A in myocardial tissues from infarct and risk regions (n=6). The addition of AG490 significantly inhibits the effect of Ad IL 23.

  • AG490