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Cat. No.: HY-182734

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BMS-357075

BMS-357075 is a pan-CDK inhibitor with CDK1 IC₅₀ 18 nM, CDK2 IC₅₀ 3 nM, CDK4 IC₅₀ 26 nM. BMS-357075 induces cytotoxicity in human ovarian cancer A2780 cells. BMS-357075 exhibits anticancer activity in mice against P388 murine leukemia. BMS-357075 can be used for the research of leukemia.

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CAS No.: 350509-99-8
화학식: C₂₂H₃₁N₅O₂S₂
분자량:461.64

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-357075 Chemical Structure

CAS No.: 350509-99-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

CDK1/cyclinB1

18 nM (IC₅₀)

CDK2/cyclinE

3 nM (IC₅₀)

CDK4/cyclin D

26 nM (IC₅₀)

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	3 nM Compound: 19	Cytotoxic effect on human ovarian (A2780) cancer cell line Cytotoxic effect on human ovarian (A2780) cancer cell line	[PMID: 15125971]

In Vitro

BMS-357075 (compound 19) potently inhibits CDK1/cyclin B (IC₅₀ = 18 nM), CDK2/cyclin E (IC₅₀ = 3 nM), and CDK4/cyclin D (IC₅₀ = 26 nM) in cell-free enzyme assays^[1].
BMS-357075 potently inhibits the viability of human ovarian cancer A2780 cells with an IC₅₀ of 3 nM^[1].
BMS-357075 shows 90% protein binding in mouse serum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BMS-357075 (compound 19) (4 mg/kg; i.p.; once daily; 7 days) produces a 56% increase in survival time (%T/C = 156) against P388 murine leukemia in immunocompetent mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 350509-99-8
분자량 461.64
화학식 C₂₂H₃₁N₅O₂S₂
SMILES

OCC(C)(CNCC1=CN=C(NC2=NC=C(SCC3=NC=C(C(C)(C)C)O3)S2)C=C1)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Misra RN, et al. Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg Med Chem Lett. 2004;14(11):2973-2977. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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