C105SR
Based on 1 Customer Validation
C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.49%
- 화학식: C32H33BrN4O3S
- 분자량:633.60
-
보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
Caspase 3 |
Caspase-7 |
Cyclophilin D 5 nM (IC50) |
C105SR (0.5/1/5/10/50/100 μM) inhibit CypD PPIase activity in Mitochondria[1].
C105SR (1μM, 4 h for hypoxia (1% O2) plus 1 h for reoxygenation (21% O2)) prevent mPTP opening [1].
C105SR (0.5/1/5/10/50/100 μM, 4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)) reducing hypoxia/reoxygenation-induced cell death in AML-12 cell[1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:AML-12 cell
-
Concentration:0.5/1/10/50/100 μM
-
Incubation Time:4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)
-
Result:Reduced LDH release and increased cell viability by approximatively 75% at 0.5μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Hepatic IRI model [1]
-
Dosage:50 mg/kg
-
Administration:Subcutaneous injection (s.c.)
-
Result:Protected mouse livers against the effects of ischaemia and reperfusion.
Chemical Information
-
Appearance Solid
-
분자량 633.60
-
화학식 C32H33BrN4O3S
-
Color White to light yellow
-
SMILES
O=C([C@@H](NC(NCC1=CC2=C(NCCC2)C=C1)=O)C3=CC(Br)=CC=C3OC)N4[C@@H](C5=C6C(C=CS6)=CC=C5)CCC4
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 250 mg/mL (394.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (278 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5783 mL | 7.8914 mL | 15.7828 mL | 39.4571 mL |
| 5 mM | 0.3157 mL | 1.5783 mL | 3.1566 mL | 7.8914 mL | |
| 10 mM | 0.1578 mL | 0.7891 mL | 1.5783 mL | 3.9457 mL | |
| 15 mM | 0.1052 mL | 0.5261 mL | 1.0522 mL | 2.6305 mL | |
| 20 mM | 0.0789 mL | 0.3946 mL | 0.7891 mL | 1.9729 mL | |
| 25 mM | 0.0631 mL | 0.3157 mL | 0.6313 mL | 1.5783 mL | |
| 30 mM | 0.0526 mL | 0.2630 mL | 0.5261 mL | 1.3152 mL | |
| 40 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9864 mL | |
| 50 mM | 0.0316 mL | 0.1578 mL | 0.3157 mL | 0.7891 mL | |
| 60 mM | 0.0263 mL | 0.1315 mL | 0.2630 mL | 0.6576 mL | |
| 80 mM | 0.0197 mL | 0.0986 mL | 0.1973 mL | 0.4932 mL | |
| 100 mM | 0.0158 mL | 0.0789 mL | 0.1578 mL | 0.3946 mL |
C105SR Related Classifications
HY-157088 Related Classifications
Powered by Bioz