Carebastine
Based on 1 publication(s) in Google Scholar
Carebastine is an Ebastine (HY-B0674) metabolite and H1-receptor antagonist. Carebastine inhibits VEGFR-2 and Akt phosphorylation. Carebastine exerts an anti-inflammatory effect by inhibiting MIF as well as TNF-α and IL-6 production. Carebastine shows anti-angiogenic activity
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- Purity : 99.23%
- CAS No.: 90729-42-3
- 화학식: C32H37NO4
- 분자량:499.64
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Carebastine
MoreAll Histamine Receptor Isoforms
MoreAll VEGFR Isoforms
More
Biological Activity
제품 설명
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H1 Receptor |
VEGFR2 |
IL-6 |
In Vitro
Carebastine (0.01-30 μM; 24-72 h) inhibits VEGF-induced proliferation of HUVECs and HPAECs in a dose-dependent manner[1].
Carebastine (1-20 μM; 18 h) inhibits VEGF-induced capillary network formation by HUVECs and HPAECs in a dose-dependent manner, causing 70-86% reduction in topological parameters at 20 μM[1].
Carebastine (10-20 μM; 5 min-24 h) inhibits VEGF-induced phosphorylation of VEGFR-2 and Akt in HUVECs and HPAECs in a time- and dose-dependent manner[1].
Carebastine (0.1-10 μmol/L; 24 h) dose-dependently reduces MIF protein secretion in costimulated human peripheral blood mononuclear cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human umbilical vein endothelial cells (HUVECs), human pulmonary artery endothelial cells (HPAECs)
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Concentration:0.01-30 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Inhibited HUVEC proliferation by 42% (48 h, p ≤ 0.03) and 64% (72 h, p ≤ 0.01) at 20 μM.
Inhibited HPAEC proliferation by 62% (48 h, p ≤ 0.03) and 75% (72 h, p ≤ 0.01) at 20 μM.
Inhibited HUVEC proliferation by 65% (72 h) at 30 μM.
Inhibited HPAEC proliferation by 80% (72 h) at 30 μM.
Chemical Information
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CAS No. 90729-42-3
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Appearance Solid
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분자량 499.64
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화학식 C32H37NO4
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Color White to light yellow
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SMILES
O=C(CCCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C4=CC=C(C=C4)C(C)(C(O)=O)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Chem
Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]2024 Jun:147:107412. PMID: 38696845
용액&용해도
In Vitro:
DMF : 25 mg/mL (50.04 mM; Need ultrasonic and warming)
DMSO : 2 mg/mL (4.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (5.00 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.00 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (273 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / DMF | 1 mM | 2.0014 mL | 10.0072 mL | 20.0144 mL | 50.0360 mL |
| DMF | 5 mM | 0.4003 mL | 2.0014 mL | 4.0029 mL | 10.0072 mL |
| 10 mM | 0.2001 mL | 1.0007 mL | 2.0014 mL | 5.0036 mL | |
| 15 mM | 0.1334 mL | 0.6671 mL | 1.3343 mL | 3.3357 mL | |
| 20 mM | 0.1001 mL | 0.5004 mL | 1.0007 mL | 2.5018 mL | |
| 25 mM | 0.0801 mL | 0.4003 mL | 0.8006 mL | 2.0014 mL | |
| 30 mM | 0.0667 mL | 0.3336 mL | 0.6671 mL | 1.6679 mL | |
| 40 mM | 0.0500 mL | 0.2502 mL | 0.5004 mL | 1.2509 mL | |
| 50 mM | 0.0400 mL | 0.2001 mL | 0.4003 mL | 1.0007 mL |
Carebastine Related Classifications
HY-121356 Related Classifications
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