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Cat. No.: HY-123826

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CCT68127

(Synonyms: αSβR-21)

CCT68127 is an orally active CDK inhibitor. CCT68127 can be used in anti-cancer research.

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CAS No.: 660822-23-1
화학식: C₁₉H₂₇N₇O
분자량:369.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CCT68127 Chemical Structure

CAS No.: 660822-23-1

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

CCT68127 is an orally active CDK inhibitor. CCT68127 can be used in anti-cancer research^[1].

IC₅₀ & Target

CDK2

CDK7

CDK9

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	1.3 μM Compound: alphaSbetaR-21, CCT68127	Inhibition of CDK7 in human HT29 cells assessed as reduction in RNA polymerase 2 expression Inhibition of CDK7 in human HT29 cells assessed as reduction in RNA polymerase 2 expression	[PMID: 21982796]
HT-29	IC₅₀	107 nM Compound: alphaSbetaR-21, CCT68127	Inhibition of CDK9 in human HT29 cells assessed as reduction in RNA polymerase 2 expression Inhibition of CDK9 in human HT29 cells assessed as reduction in RNA polymerase 2 expression	[PMID: 21982796]

Chemical Information

CAS No. 660822-23-1
분자량 369.46
화학식 C₁₉H₂₇N₇O
SMILES

C[C@@H](O)[C@@H](NC1=NC(NCC2=CC=CN=C2)=C3N=CN(C(C)C)C3=N1)CC
Synonyms

αSβR-21
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wilson SC, et al. Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors. Bioorg Med Chem. 2011 Nov 15;19(22):6949-65. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
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CCT68127

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CCT68127 Related Classifications

HY-123826 Related Classifications