Cdc7-IN-20
Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC50 and Ki values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity.
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- 화학식: C15H16N4OS
- 분자량:300.38
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Cdc7-IN-20 (0.5, 1, 2 μM, 24 h) can inhibit the proliferation of COLO 205 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:COLO 205
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Concentration:0.5, 1, 2 μM
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Incubation Time:24 h
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Result:Inhibited the phosphorylation at Ser53 and Ser40 of MCM2 in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:COLO 205 xenograft mice model[1]
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Dosage:2, 4, 8 mg/kg
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Administration:p.o. for 3 consecutive days
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Result:Inhibit the expression of p-MCM2 protein.
Chemical Information
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분자량 300.38
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화학식 C15H16N4OS
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SMILES
O=C1NC(C(N)C(C)C)=NC2=C1SC(C3=CC=NC=C3)=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cdc7-IN-20 Related Classifications
HY-163374 Related Classifications
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