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Cat. No.: HY-184444

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CDK4-IN-7

CDK4-IN-7 is a CDK4 inhibitor with an IC₅₀ of 26 nM. CDK4-IN-7 shows selectivity for CDK1, with an IC₅₀ of 4.2262 μM. CDK4-IN-7 can be used in cancer research.

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CAS No.: 3113087-01-4
화학식: C₂₀H₂₈F₂N₆O₂S
분자량:454.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK4-IN-7 Chemical Structure

CAS No.: 3113087-01-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

CDK4-IN-7 is a CDK4 inhibitor with an IC₅₀ of 26 nM. CDK4-IN-7 shows selectivity for CDK1, with an IC₅₀ of 4.2262 μM. CDK4-IN-7 can be used in cancer research^[1].

IC₅₀ & Target^[1]

CDK4

26 nM (IC₅₀)

CDK1

4.2262 μM (IC₅₀)

All CDK Isoforms :

In Vitro

CDK4-IN-7 (Compound 5) potently inhibits CDK4 with an IC₅₀ of 26 nM and shows 162.5-fold selectivity for CDK4 over CDK1 in a biochemical kinase assay measuring retinoblastoma protein Ser⁷⁸⁰ phosphorylation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3113087-01-4
분자량 454.54
화학식 C₂₀H₂₈F₂N₆O₂S
SMILES

CC1=CC2=CN=C(N[C@H]3[C@H](F)CN(S(C4CC4)(=O)=O)CC3)N=C2N1[C@@H]5CCNC[C@@H]5F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jiang, Y., & Liang, S. H. (2026). Pyridine Derivatives as Cyclin-Dependent Kinase Inhibitors for the Treatment of Cancer. ACS Medicinal Chemistry Letters.

Calculators

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Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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CDK4-IN-7

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CDK4-IN-7 Related Classifications

HY-184444 Related Classifications