Dalpiciclib isethionate
Based on 2 publication(s) in Google Scholar
Dalpiciclib (isethionate) is a CDK4/6 inhibitor. Dalpiciclib (isethionate) inhibits the kinase activity of CDK4 and CDK6, thereby blocking the G1-to-S phase transition of the cell cycle and suppressing abnormal cell proliferation. Dalpiciclib (isethionate) can be used for the study of breast cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1980822-14-7
- 화학식: C27H36N6O6S
- 분자량:572.68
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Dalpiciclib isethionate
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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IF
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WB
Biological Activity
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CDK4 |
CDK6 |
Chemical Information
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CAS No. 1980822-14-7
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분자량 572.68
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화학식 C27H36N6O6S
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SMILES
O=C1C(C(C)=O)=C(C)C2=C(N1C3CCCC3)N=C(NC4=NC=C(C5CCNCC5)C=C4)N=C2.O=S(O)(CCO)=O
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Synonyms
SHR-6390 isethionate
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
The CDK4/6 inhibitor dalpiciclib augments the antitumor efficacy of enzalutamide in preclinical models of castration-resistant prostate cancer through inhibition of MCM4-mediated DNA replication. [Abstract]2026 Jun 5. PMID: 42248826
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
22Rv1 and C4-2B cells were treated for 48 h with ENZ and DAL in a fixed-ratio combination (10:1), with 2-fold serial dilutions of ENZ (10–160 μM) and Dalpiciclib (DAL) (1–16 μM).
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Representative images of colony formation assays in 22Rv1 and C4-2B cells treated with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination for 12–17 days.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Representative immunofluorescence images of BrdU incorporation assays in 22Rv1 and C4-2B cells treated with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination for 48 h.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Representative Annexin V/PI flow cytometry plots showing apoptosis in 22Rv1 and C4-2B cells after 48-hour treatment with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Western blot analysis of cell cycle-related proteins in 22Rv1 and C4-2B cells treated with or without ENZ (35 μM) and/or Dalpiciclib (DAL) (2 μM) for 48 h.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Representative images of wound-healing assays conducted on 22Rv1 and C4-2B cells treated with DMSO, ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or ENZ (35 μM) + DAL (2 μM) for 24 h.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Bioluminescence imaging and representative photographs of excised popliteal lymph nodes from nude mice at the experimental endpoint (day 28) treated with Dalpiciclib (DAL) (75 mg/kg, i.g.).
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순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dalpiciclib isethionate Related Classifications
HY-114338B Related Classifications
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