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Cat. No.: HY-175988

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DNMT/HDAC-IN-2

DNMT/HDAC-IN-2 (Compound Y7) is a DNMT and HDAC inhibitor with IC₅₀ values for DNMT1, HDAC1, and HDAC6 of 365, 0.2, and 8.91 nM respectively. DNMT/HDAC-IN-2 inhibits the proliferation of breast cancer cells. DNMT/HDAC-IN-2 significantly reduces tumor growth in xenografts and transgenic breast cancer mouse models. DNMT/HDAC-IN-2 can be used for the study of breast cancer.

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CAS No.: 2548725-57-9
화학식: C₂₈H₃₈N₄O₅
분자량:510.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DNMT/HDAC-IN-2 Chemical Structure

CAS No.: 2548725-57-9

사이즈

가격

재고

수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

HDAC1

0.2 nM (IC₅₀)

HDAC6

8.91 nM (IC₅₀)

DNMT1

365 nM (IC₅₀)

All DNA Methyltransferase Isoforms :

All HDAC Isoforms :

Chemical Information

CAS No. 2548725-57-9
분자량 510.63
화학식 C₂₈H₃₈N₄O₅
SMILES

COC1=C(C=C(C2=C1)N=C(C=C2NC3CCN(CC3)C)C4=CC=C(O4)C)OCCCCCCC(NO)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin H, et al. Design, Synthesis, and Biological Evaluation of Quinoline-Based Hydroxamic Acid Derivatives as Dual DNMT and HDAC Inhibitors with Potent Anti-Breast Cancer Activity. J Med Chem. 2025 Sep 25;68(18):19022-19040. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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DNMT/HDAC-IN-2

All DNA Methyltransferase Isoforms

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DNMT/HDAC-IN-2 Related Classifications

HY-175988 Related Classifications