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Cat. No.: HY-149261

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H1k

H1k, a Eudistomin Y derivative, is a lysosome-targeted antiproliferation agent. H1k increases the autophagy signal and downregulate the expression of cyclin-dependent kinase (CDK1) and cyclin B1. H1k can be used in research of cancer.

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CAS No.: 3039928-21-4
화학식: C₂₆H₂₀N₂O₂
분자량:392.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

H1k Chemical Structure

CAS No.: 3039928-21-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	14.8 μM Compound: H1k	Cytotoxicity against human A549 cells assessed as cell inhibition measured after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell inhibition measured after 72 hrs by MTT assay	[PMID: 36774698]
HepG2	IC₅₀	9.6 μM Compound: H1k	Cytotoxicity against human HepG2 cells assessed as cell inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell inhibition measured after 72 hrs by MTT assay	[PMID: 36774698]
LS180	IC₅₀	2.9 μM Compound: H1k	Cytotoxicity against human LS180 cells assessed as cell inhibition measured after 72 hrs by MTT assay Cytotoxicity against human LS180 cells assessed as cell inhibition measured after 72 hrs by MTT assay	[PMID: 36774698]
MDA-MB-231	IC₅₀	20.5 μM Compound: H1k	Cytotoxicity against human MDA-MB-231 cells assessed as cell inhibition measured after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as cell inhibition measured after 72 hrs by MTT assay	[PMID: 36774698]
SGC-7901	IC₅₀	12.1 μM Compound: H1k	Cytotoxicity against human SGC-7901 cells assessed as cell inhibition measured after 72 hrs by MTT assay Cytotoxicity against human SGC-7901 cells assessed as cell inhibition measured after 72 hrs by MTT assay	[PMID: 36774698]

In Vitro

H1k (72 h) has antiproliferation activity against LS-180, HepG-2, SGC-7901, A549 and MDA-MB-231 cells with IC₅₀ values of 2.9, 9.6, 12.1, 14.8, and 20.5 μM, respectively^[1].
H1k (0-50 μM; 24 h) triggers a distinct G2-M arrest in the MDA-MB-231 and SGC-7901 cells in a dose-dependent manner^[1].
H1k (0-20 μM; 6 h; MDA-MB-231 cells) induces autophagy to exert its antiproliferative activity, and lysosomes are its functional targets^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-231 and SGC-7901 cells
Concentration:

0, 5, 10, 20, 50 μM
Incubation Time:

24 hours
Result:

Arrested cell cycle at G2-M period in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231 and SGC-7901 cells
Concentration:

0, 5, 10, and 20 μM
Incubation Time:

6 hours
Result:

Increased the LC3B-I and LC3B-II levels at MDA-MB-231 cells in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231 and SGC-7901 cells
Concentration:

0, 5, 10, 20, 50 μM
Incubation Time:

6 hours
Result:

Inhibited antiproliferation of cancer cells and the downregulation of CDK1 and cyclin B1.

Chemical Information

CAS No. 3039928-21-4
분자량 392.45
화학식 C₂₆H₂₀N₂O₂
SMILES

COC1=CC=C(C=C1)CN2C3=C(C4=C2C(C(C5=CC=CC=C5)=O)=NC=C4)C=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang G, et, al. Design, synthesis, and discovery of Eudistomin Y derivatives as lysosome-targeted antiproliferation agents. Eur J Med Chem. 2023 Mar 15;250:115193. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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H1k

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

H1k Related Classifications

HY-149261 Related Classifications