HS-36
HS-36 is a highly selective and orally active dual inhibitor of CDK4 and CDK9 with IC50 values of 18.9 and 4.2 nM respectively. HS-36 exhibits nanomolar-level potent activity against various cancer cells, inducing G0/G1 phase arrest and promoting cell apoptosis. HS-36 efficiently inhibits tumor growth in a mouse model of MV-4-11 tumors. HS-36 can be used for the study of acute myeloid leukemia.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C24H25N3O5
- 분자량:435.47
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
CDK9 4.2 nM (IC50) |
CDK4 18.9 nM (IC50) |
CDK2 197.3 nM (IC50) |
CDK6 125.5 nM (IC50) |
CDK9 216.9 nM (IC50) |
CDK1 > 500 nM (IC50) |
CDK7 > 500 nM (IC50) |
CDK12 > 500 nM (IC50) |
Chemical Information
-
분자량 435.47
-
화학식 C24H25N3O5
-
SMILES
O=C1C2=C(C=C3C(N(C(O3)=O)[C@H](C)CC)=C2OC(C4=CC=C(C=C4)N5CCNCC5)=C1)O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HS-36 Related Classifications
HY-180912 Related Classifications
Powered by Bioz