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Cat. No.: HY-170692

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Hypoglycemic agent 3

Hypoglycemic agent 3 (Compound H26), a derivative of corosolic acid, exhibits lipid-lowering and significant hypoglycemic effects and can be used as a hypoglycemic agent. Hypoglycemic agent 3 inhibits insulin resistance by targeting MCCC1 and can be used in the study of type 2 diabetes.

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화학식: C₃₂H₅₁NO₅
분자량:529.75

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Hypoglycemic agent 3 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Akt Isoforms :

All NF-κB Isoforms :

All PI3K Isoforms :

In Vitro

Hypoglycemic agent 3 (Compound H26) (40-320 μM; 24 h) shows no significant cytotoxicity in HepG2 cells^[1].
Hypoglycemic agent 3 (20-40 μM) suppresses insulin resistance primarily by increasing MCCC1 in HepG2 cells^[1].
Hypoglycemic agent 3 (20 μM; 1 h) significantly inhibits the increase in glucose production induced by glucosamine (18 mM; 18 h) (HY-B1125) in HepG2 cells^[1].
Hypoglycemic agent 3 (2.5-20 μM; 1 h) can activate PI3K-AKT and inhibit NF-κB signaling pathway in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HepG2
Concentration:

2.5, 10, 20 μM
Incubation Time:

1 h
Result:

Ehanced the phosphorylation levels of KT and GSK3β.
Sgnificantly increased the expression of IκBα, suggesting that H26 may inhibit the activation of NF-κB.

Chemical Information

분자량 529.75
화학식 C₃₂H₅₁NO₅
SMILES

O=C(O)CNC([C@]12CC[C@@H](C)[C@H](C)[C@@]1([H])C3=CCC4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC2)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang G, et al. Corosolic acid and its derivatives targeting MCCC1 against insulin resistance and their hypoglycemic effect on type 2 diabetic mice[J]. European Journal of Medicinal Chemistry, 2024: 117184. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Hypoglycemic agent 3

All Akt Isoforms

All NF-κB Isoforms

All PI3K Isoforms