iMPZ-8
iMPZ-8 is a β-tubulin polymerization inhibitor that inhibits β-tubulin protein expression, disrupts microtubule structure, impairs microtubule organization. iMPZ-8 inhibits proliferation and reduces cellular migration and colonization in cancer cells. iMPZ-8 induces G2/M phase arrestand induces apoptosis via the BAX-Caspase-3 intrinsic apoptotic signaling pathway. iMPZ-8 can be used for the research of cancer, suah as breast cancer, neuroblastoma and colon cancer.
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- 화학식: C23H18N4O2
- 분자량:382.41
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Bax |
Bcl-2 |
Caspase 3 |
iMPZ-8 (1-80 μM; 72 h) potently inhibits proliferation in MDA-MB-231, SH-SY5Y, and DLD-1 cancer cells with IC50 values of 7.5 μM, 9.2 μM, and 19.7 μM, respectively[1].
iMPZ-8 (3 μM; 48 h) significantly inhibits β-tubulin expression and disrupts microtubule structure in MDA-MB-231 cells, with efficacy similar to nocodazole[1].
iMPZ-8 (3 μM; 48 h) inhibits migration in MDA-MB-231 cells by approximately 50%[1].
iMPZ-8 (3 μM; 7 to 10 days) reduces colony formation in MDA-MB-231 cells by approximately 30%[1].
iMPZ-8 (3 μM; 48 h) induces G2/M phase cell cycle arrest in MDA-MB-231 cells[1].
iMPZ-8 (3 μM; 48 h) induces intrinsic apoptosis via the BAX-Caspase-3 pathway in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, SH-SY5Y, DLD-1
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Concentration:1-80 μM
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Incubation Time:72 h
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Result:Exhibited antiproliferative activity with IC50 values of 7.5 μM in MDA-MB-231 cells, 9.2 μM in SH-SY5Y cells, and 19.7 μM in DLD-1 cells.
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Cell Line:MDA-MB-231
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Concentration:3 μM
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Incubation Time:48 h
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Result:Markedly inhibited β-tubulin protein expression, with effects comparable to Nocodazole (HY-13520) (a known β-tubulin antagonist).
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Cell Line:MDA-MB-231
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Concentration:3 μM
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Incubation Time:48 h
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Result:Induced accumulation of cells in the G2/M phase of the cell cycle, similar to Nocodazole.
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Cell Line:MDA-MB-231
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Concentration:3 μM
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Incubation Time:48 h
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Result:Induced accumulation in early and late apoptosis.
Increased BAX and Caspase 3 levels and reduced Bcl-2 levels.
Chemical Information
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분자량 382.41
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화학식 C23H18N4O2
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SMILES
CC1=CC=C(C2=NN=C(C3=C(C4=CC=C(OC)C=C4)N=C5C=CC=CN53)O2)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
iMPZ-8 Related Classifications
HY-181019 Related Classifications
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