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Cat. No.: HY-129694

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Lenoremycin

(Synonyms: Ro 21-6150; Antibiotic A-130-A)

Lenoremycin (Ro 21-6150) is a microbial metabolite. Lenoremycin decreases β-catenin and cyclin D1 proteins levels. Lenoremycin decreases cancer stem cells (CSCs) populations via inducing reactive oxygen species production.

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CAS No.: 51257-84-2
화학식: C₄₇H₇₈O₁₃
분자량:851.11

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Lenoremycin Chemical Structure

CAS No.: 51257-84-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.2 μM Compound: 9	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by resazurin assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by resazurin assay	[PMID: 28029795]
HEK293	EC₅₀	38 nM Compound: 9	Modulation of unfolded protein response in tunicamycin-treated HEK293 cells after 48 hrs by ASGR-Cluc secretion assay Modulation of unfolded protein response in tunicamycin-treated HEK293 cells after 48 hrs by ASGR-Cluc secretion assay	[PMID: 28029795]

Chemical Information

CAS No. 51257-84-2
분자량 851.11
화학식 C₄₇H₇₈O₁₃
SMILES

C[C@H]1[C@]2(O[C@](C[C@H]1O[C@@H]3O[C@@H]([C@H](CC3)OC)C)([H])[C@@H](C)/C=C(C)/C([C@H](C)C[C@H](C)C(O)=O)=O)O[C@@](CC2)([C@]4([H])O[C@@]5([C@@H](CC4)C)O[C@]([C@@]6([H])O[C@](O)([C@@H](C[C@@H]6C)C)CO)([H])C[C@@H]5C)C
Synonyms

Ro 21-6150; Antibiotic A-130-A
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces hygroscopicus
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ikeda H, et al. Identification of the polyether ionophore lenoremycin through a new screening strategy for targeting cancer stem cells. J Antibiot (Tokyo). 2022 Dec;75(12):671-678. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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Lenoremycin

All CDK Isoforms