Nyasol
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells.
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- CAS No.: 96895-25-9
- 화학식: C17H16O2
- 분자량:252.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | IC50 |
>100 μM
Compound: 4
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Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining
Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining
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[PMID: 19757853] |
| Col2 | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
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[PMID: 14987058] |
| HUVEC | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against HUVEC
Cytotoxicity against HUVEC
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[PMID: 14987058] |
| KB | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 14987058] |
| LNCaP | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 14987058] |
| Lu1 | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
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[PMID: 14987058] |
| Lymphocyte | IC50 |
200 μM
Compound: 2, (+)-nyasol
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Inhibition of phytohemagglutininin A-induced human lymphocyte proliferation assessed as radiolabeled [14C]thymidine uptake
Inhibition of phytohemagglutininin A-induced human lymphocyte proliferation assessed as radiolabeled [14C]thymidine uptake
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[PMID: 9358645] |
Chemical Information
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CAS No. 96895-25-9
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분자량 252.31
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화학식 C17H16O2
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SMILES
C=C[C@@H](C1=CC=C(O)C=C1)/C=C\C2=CC=C(O)C=C2
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Synonyms
(-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Lim H, et al. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32(11):1509-14. [Content Brief]
[2]. Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66(5):435-8. [Content Brief]
[3]. Lee HJ, et al. (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28(5):954-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nyasol Related Classifications
HY-138050 Related Classifications
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