Nyasol
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells.
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- CAS No.: 96895-25-9
- 화학식: C17H16O2
- 분자량:252.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | IC50 |
>100 μM
Compound: 4
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Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining
Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining
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[PMID: 19757853] |
| Col2 | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
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[PMID: 14987058] |
| HUVEC | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against HUVEC
Cytotoxicity against HUVEC
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[PMID: 14987058] |
| KB | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 14987058] |
| LNCaP | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 14987058] |
| Lu1 | IC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
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[PMID: 14987058] |
| Lymphocyte | IC50 |
200 μM
Compound: 2, (+)-nyasol
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Inhibition of phytohemagglutininin A-induced human lymphocyte proliferation assessed as radiolabeled [14C]thymidine uptake
Inhibition of phytohemagglutininin A-induced human lymphocyte proliferation assessed as radiolabeled [14C]thymidine uptake
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[PMID: 9358645] |
Chemical Information
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CAS No. 96895-25-9
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분자량 252.31
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화학식 C17H16O2
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SMILES
C=C[C@@H](C1=CC=C(O)C=C1)/C=C\C2=CC=C(O)C=C2
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Synonyms
(-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
[1]. Lim H, et al. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32(11):1509-14. [Content Brief]
[2]. Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66(5):435-8. [Content Brief]
[3]. Lee HJ, et al. (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28(5):954-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nyasol Related Classifications
HY-138050 Related Classifications
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