Perfluoroundecanoic acid
Based on 1 Customer Validation
Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation.
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- Purity: 99.85%
- CAS No.: 2058-94-8
- 화학식: C11HF21O2
- 분자량:564.09
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Perfluoroundecanoic acid (2-16 μM, 24 h) promotes M2 polarization of RAW264.7 macrophages by increasing the protein and mRNA levels of M2 markers (ARG1, CD163, TGF-β) and decreasing M1 marker (iNOS)[1].
Perfluoroundecanoic acid (8 μM, 24 h) activates Wnt/β-catenin signaling in RAW264.7 cells, enhancing β-catenin expression and nuclear translocation[1].
Perfluoroundecanoic acid (8 μM, 24 h)-pretreated RAW264.7 cell conditioned medium promotes migration and invasion of A2780 and SKOV3 ovarian cancer cells, which is reversed by β-catenin inhibitor ICG001 (HY-14428)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:2, 4, 8, 16 μM
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Incubation Time:24 h
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Result:Increased protein levels of M2 markers (ARG1, CD163) and decreased M1 marker (iNOS), with the most significant changes at 8 μM.
Increased β-catenin protein level and nuclear translocation; no significant changes in p-smad2, p-smad3, p-Akt, p-mTOR, or PPARα.
Perfluoroundecanoic acid (0-10 mg/kg, p.o., daily, 21-35 days) inhibits Leydig cell development and function via oxidative stress and autophagy in pubertal male Sprague-Dawley rats[2].
Perfluoroundecanoic acid (3-300 μg/L in drinking water, from mating through gestation, lactation and until 30 weeks of age) accelerates insulitis development in a mouse model of type 1 diabetes[3].
Perfluoroundecanoic acid (0.1-1.0 mg/kg, p.o., daily, 28-35 days) induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5-week-old female BALB/c nude mice were intraperitoneally coinjected pretreated RAW264.7 cells and SKOV3 cells, with observation for 4 weeks[1]
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Dosage:8 μM pretreated RAW264.7 cells
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Administration:Co-injected intraperitoneally with SKOV3 cells for 4 weeks
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Result:Increased the number and weight of ovarian cancer metastatic nodules.
Reduced the number and weight of ovarian cancer metastatic nodules in the above mouse model when pretreated with β-catenin inhibitor ICG001.
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Animal Model:35 days old Sprague-Dawley rats[2]
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Dosage:1, 5, 10 mg/kg
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Administration:p.o. daily for 21-35 days
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Result:Reduced serum testosterone at ≥1 mg/kg; no effect on serum estradiol.
Reduced serum LH at ≥1 mg/kg and serum FSH at 5 and 10 mg/kg.
Down-regulated expression of Lhb and Fshb in the pituitary at 5 and/or 10 mg/kg; up-regulated Gnrhr expression at 10 mg/kg.
Reduced Leydig cell number (CYP11A1-positive and HSD11B1-positive) at 5 and 10 mg/kg; no effect on Sertoli cell number.
Down-regulated expression of steroidogenesis-related genes (Lhcgr, Scarb1, Star, Cyp11a1) and their proteins in the testis at various doses.
Reduced sperm in the epididymis caput, corpus, and cauda at 10 mg/kg.
Increased testicular triglyceride levels at 5 and 10 mg/kg; no effect on testicular total cholesterol.
Down-regulated expression of Sod1 and Sod2 in the testis at various doses; increased MDA levels at 10 mg/kg.
Increased LC3B and p62 levels.
Reduced Beclin1 at 5 and 10 mg/kg.
Reduced phosphorylation of mTOR, AKT1, AKT2, and ERK1/2.
Reduced BCL2 levels at 5 and 10 mg/kg; increased BAX level at 10 mg/kg.
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Animal Model:Female non-obese diabetic (NOD) mice (offspring of 8-week-old females and 10-week-old males)[3]
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Dosage:3, 30, 300 μg/L in drinking water
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Administration:p.o. from mating through gestation, lactation and until 30 weeks of age
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Result:Increased pancreatic insulitis grade at 11 weeks of age (300 μg/L).
Increased number of apoptotic cells in pancreatic islets with insulitis grade 0 at 11 weeks of age (300 μg/L).
Reduced peritoneal macrophage phagocytosis at 7 weeks of age (300 μg/L).
Increased ConA-induced IL-2 secretion and decreased LPS-induced IL-6 secretion in splenocytes at 11 weeks of age (3 μg/L).
Showed a trend of increased ConA-induced IL-6 and IFN-γ secretion in splenocytes at 11 weeks of age (300 μg/L).
Had no significant effect on accelerating diabetes development, and low doses (3, 30 μg/L) tended to reduce diabetes incidence.
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Animal Model:Male Swiss mice (8 or 13 weeks old)[4]
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Dosage:0.1, 0.3, 0.5, 0.7, 1.0 mg/kg
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Administration:p.o. for 28-35 days
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Result:Induced significant hepatic DNA damage.
Caused reproductive toxicity: reduced sperm count and motility, increased sperm abnormalities; elevated serum LH and FSH, reduced testosterone; testicular atrophy and histopathological lesions.
Altered hematological parameters: decreased PCV, Hb, platelets, RBC count and indices; increased WBC and neutrophils.
Disrupted clinical biochemistry: elevated AST, ALT, urea, total cholesterol, triglyceride; reduced ALP, albumin, creatinine, HDL.
Induced oxidative stress in liver and testis: increased SOD, CAT, GST, MDA; reduced GPx, GSH.
Caused histopathological lesions in liver (cellular infiltration, venous congestion) and kidney (interstitial congestion, tubular lumen expansion); no spleen lesions.
Chemical Information
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CAS No. 2058-94-8
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Appearance Solid
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분자량 564.09
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화학식 C11HF21O2
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Color White to off-white
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SMILES
O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)F)F)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 175 mg/mL (310.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (283 KB)
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SDS (558 KB)
- English - EN (558 KB)
- Français - FR (558 KB)
- Deutsch - DE (558 KB)
- Norwegian - NO (558 KB)
- Español - ES (558 KB)
- Swedish - SV (558 KB)
- Italian - IT (558 KB)
- Korean - KR (558 KB)
- Portuguese - PT (558 KB)
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Handling Instructions (2659 KB)
References
[1]. Cui Z, et al. PFDA promotes cancer metastasis through macrophage M2 polarization mediated by Wnt/β-catenin signaling. Chemosphere. 2024 Aug;362:142758. [Content Brief]
[2]. Yan H, et al. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Toxicol Appl Pharmacol. 2021 Mar 15;415:115440. [Content Brief]
[3]. Bodin J, et al. Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes. Toxicol Rep. 2016 Aug 29;3:664-672. [Content Brief]
[4]. Ogunsuyi OM, et al. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Chemosphere. 2023 Oct;338:139491. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7728 mL | 8.8638 mL | 17.7277 mL | 44.3192 mL |
| 5 mM | 0.3546 mL | 1.7728 mL | 3.5455 mL | 8.8638 mL | |
| 10 mM | 0.1773 mL | 0.8864 mL | 1.7728 mL | 4.4319 mL | |
| 15 mM | 0.1182 mL | 0.5909 mL | 1.1818 mL | 2.9546 mL | |
| 20 mM | 0.0886 mL | 0.4432 mL | 0.8864 mL | 2.2160 mL | |
| 25 mM | 0.0709 mL | 0.3546 mL | 0.7091 mL | 1.7728 mL | |
| 30 mM | 0.0591 mL | 0.2955 mL | 0.5909 mL | 1.4773 mL | |
| 40 mM | 0.0443 mL | 0.2216 mL | 0.4432 mL | 1.1080 mL | |
| 50 mM | 0.0355 mL | 0.1773 mL | 0.3546 mL | 0.8864 mL | |
| 60 mM | 0.0295 mL | 0.1477 mL | 0.2955 mL | 0.7387 mL | |
| 80 mM | 0.0222 mL | 0.1108 mL | 0.2216 mL | 0.5540 mL | |
| 100 mM | 0.0177 mL | 0.0886 mL | 0.1773 mL | 0.4432 mL |
Perfluoroundecanoic acid Related Classifications
HY-W142432 Related Classifications
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