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Cat. No.: HY-180412

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Solimastat

(Synonyms: BB-3644)

Solimastat (BB-3644) is a potent metalloproteinase (MMP) inhibitor that blocks constitutive and antibody-stimulated CD30 shedding from cell surfaces with an IC₅₀ of 180 nM. Solimastat enhances persistence of anti-CD30 antibody Ki-3 on cells and favors its internalization. Solimastat enhances cytotoxic activity of Ki-3.dgA towards CD30⁺ L540 cells. Solimastat can be used for the research of CD30⁺ malignancies.

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CAS No.: 226072-63-5
화학식: C₂₀H₃₂N₄O₅
분자량:408.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Solimastat Chemical Structure

CAS No.: 226072-63-5

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All MMP Isoforms :

In Vitro

Solimastat (0-10⁵ nM, 10 min) potently inhibits PMA (HY-18739)-induced CD30 shedding from Karpas 299 cells in a dose-dependent manner^[1].
Solimastat (5 μM; 12 h) significantly increases internalization and surface persistence of Ki-3 MAb in Karpas 299 cells, while showing no effect on the process of antibody endocytosis itself^[1].
Solimastat (5 μM; 48 h) increases the cytotoxic activity of Ki-3.dgA immunotoxin against L540 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

CD30⁺ L540 and CD30^- HD-MyZ cells
Concentration:

5 μM
Incubation Time:

48 h
Result:

Had no influence on the cell viability of L540 and HD-MyZ cells alone.
Increased cytotoxic activity of Ki-3.dgA immunotoxin against L540 cells, with IC₅₀ shifts from 0.34 nM to 18.3 nM.

Chemical Information

CAS No. 226072-63-5
분자량 408.50
화학식 C₂₀H₃₂N₄O₅
SMILES

[C@@H]([C@@H](C(NO)=O)OC)(C(N[C@H](C(NC1=CC=CC=N1)=O)[C@@](C)(C)C)=O)CC(C)C
Synonyms

BB-3644
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002;98(2):210-215. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
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Solimastat

All MMP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Solimastat Related Classifications

HY-180412 Related Classifications