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Cat. No.: HY-184342

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SYC-2863

SYC-2863 is a CRBN-recruiting PROTAC degrader that selectively degrades ENL (MLLT1), with an ENL DC₅₀ of 45 nM in MV4;11 cells. SYC-2863 inhibits the proliferation of MLL-rearranged leukemia and multiple myeloma cells. After degrading intracellular ENL, SYC-2863 dose-dependently downregulates the transcription levels of MYC and its downstream target genes, blocking the MYC-mediated malignant proliferation pathway. SYC-2863 can be used in studies related to MLL-rearranged leukemia and multiple myeloma.

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화학식: C₄₂H₄₇N₉O₅
분자량:757.88

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SYC-2863 Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
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Bioz

Biological Activity

제품 설명

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

SYC-2863 (compound 14) (0-1000 nM; 24 h) potently and selectively degrades ENL (DC₅₀ = 45 nM, D_max = 97%) without altering AF9 levels in MV4;11 cells^[1].
SYC-2863 selectively inhibits proliferation of Molm-13 (EC₅₀ = 0.13 μM) and MV4;11 (EC₅₀ = 2.1 μM) MLL-rearranged leukemia cells, with weaker activity against RPMI-8226 multiple myeloma cells and no activity against HeLa solid tumor cells^[1].
SYC-2863 (2 μM; 0-60 min) undergoes rapid NADPH-dependent metabolic degradation in human liver microsomes, with an in vitro half-life of 11.6 minutes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 757.88
화학식 C₄₂H₄₇N₉O₅
SMILES

O=C1CCC(N2C(C(C=CC=C3NCCCCCCCCN4C(C=CC(C(NC5=CC(NC(CN6[C@@H](C)CCC6)=C7)=C7C=N5)=O)=C8)=C8C=N4)=C3C2=O)=O)C(N1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Li X, et al.. Synthesis, structure-activity relationships, antitumor activities and mechanistic studies of ENL-degrading compounds. European journal of medicinal chemistry. 2026 May 19;316:118989. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
순도&문서
References

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SYC-2863

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SYC-2863 Related Classifications

HY-184342 Related Classifications