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Topotecan

(Synonyms: SKF 104864A; NSC 609669)
40 Cited Publications
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Based on 40 publication(s) in Google Scholar

Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity.

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  • Purity : 98.04%
  • CAS No.: 123948-87-8
  • 화학식: C23H23N3O5
  • 분자량:421.45
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Topotecan Chemical Structure
    Topotecan Chemical Structure
  • Experimental Validation Results for Topotecan
  • Experimental Validation Results for Topotecan
  • Experimental Validation Results for Topotecan
  • Experimental Validation Results for Topotecan
  • Experimental Validation Results for Topotecan
CAS No.: 123948-87-8
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In Vivo Efficacy StudyFlow CytometryCell Proliferation/Viability AssayIFWB
  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
  • Flow Cytometry
  • IF
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All Topoisomerase Isoforms

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  • Topotecan Chemical Structure
    Topotecan Chemical Structure
    1/16
  • 1/16

    Topotecan purchased from MedChemExpress. Usage Cited in: NPJ Precis Oncol. 2024 Jun 5;8(1):128. [Abstract]

    Customer Validation
     Topotecan hydrochloride (0.0001-100 μM; 48 h). Dose-response curves after various concentrations of chemotherapeutic drugs in DYRK1A-KOs and NT-KOs for HCT-116 cell.

  • 1/16

    Topotecan purchased from MedChemExpress. Usage Cited in: Cancer Res. 2023 Dec 15;83(24):4015-4029. [Abstract]

    Customer Validation
     Topotecan hydrochloride (10 mg/kg; ip). Tumor weights from 10A.PM xenografts after Topotecan treatment.

  • 1/16

    Topotecan purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2022 Apr;11(4):e12206. [Abstract]

    Customer Validation
     Topotecan hydrochloride (20 μM; 48 h). Bivariate dot‐plots of SYTO 16 fluorescence versus EV size of EVs for EV preparations from HCT‐15 cells treated with DMSO control (i), etoposide (ii), SN‐38 (iii) or topotecan (iv).

  • 1/16

    Topotecan purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]

    Customer Validation
     Topotecan (10 mg/kg; Intraperitoneal injection). Representative images and the apoptotic rate the indicated chemotherapy-treated xenograft tumors.

  • 1/16

    Topotecan purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]

    Customer Validation
     Topotecan (10 mg/kg; Intraperitoneal injection). IB analysis of the level of cleaved-caspase 3 and cleaved-PARP1 in the indicated chemotherapy-treated xenograft tumors. GAPDH served as the loading control.

  • Topotecan