YY173
YY173 is a dual inhibitor for CDK4 and CDK6 with IC50 of 7.7 and 88 nM. YY173 inhibits the proliferation of cell Jurkat with an IC50 of 1.46 μM. YY173 can be used for synthesis of PROTAC CDK4/6 degrader 1 (HY-163786).
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- CAS No.: 330550-51-1
- 화학식: C21H25N7O
- 분자량:391.47
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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CDK4 7.7 nM (IC50) |
CDK6 88 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
1.466 μM
Compound: YY173
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Anti-proliferative activity against human Jurkat cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay
Anti-proliferative activity against human Jurkat cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay
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[PMID: 38943626] |
YY173 (72 h) is a CDK4/6 inhibitor ligand and shows antiproliferative effect in Jurkat cells with an IC50 value of 1.466 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 330550-51-1
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분자량 391.47
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화학식 C21H25N7O
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SMILES
O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCNCC4)=NC=C2N=C1)C5CCCC5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YY173 Related Classifications
HY-163787 Related Classifications
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