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Ponatinib hydrochloride

(Synonyms: AP24534 hydrochloride)
57 Cited Publications
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Based on 57 publication(s) in Google Scholar

Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

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  • Reinheit : 99.76%
  • CAS. Nr.: 1114544-31-8
  • Formel: C29H28ClF3N6O
  • Molecular Weight:569.02
  • Speicherung:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Ponatinib hydrochloride Chemical Structure
    Ponatinib hydrochloride Chemical Structure
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
CAS. Nr.: 1114544-31-8
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Publications Citing Use of MedChemExpress (MCE) Ponatinib hydrochloride

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WBCell Imaging/StainingIn Vivo Efficacy StudyCell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • Cell Imaging/Staining
  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • WB
  • WB

Alle Bcr-Abl Isoform-spezifische Produkte anzeigen

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Alle PDGFR Isoform-spezifische Produkte anzeigen

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Alle VEGFR Isoform-spezifische Produkte anzeigen

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  • Ponatinib hydrochloride Chemical Structure
    Ponatinib hydrochloride Chemical Structure
    1/16
  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Jan:286:138305. [Abstract]

    Customer Validation
     KBM5-T315I cells were treated with the indicated concentrations of CX-4945, Ponatinib (0.001-10 μM), or with two combined drugs by simultaneously increasing their concentration at the ratio of 1:500 for Ponatinib + CX-4945. Viability was assessed by the MTT method after 48 h treatment and expressed as percentage of vehicle-treated controls.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Nov:180:117569. [Abstract]

    Customer Validation
     Ponatinib inhibited proliferation of CCA cell lines. Relative viability (%) of KKU-100 and KKU-213A cells after 48 h treatment with buparlisib, Ponatinib and the combination of both drugs (0.25-5 μM).

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Nov:180:117569. [Abstract]

    Customer Validation
     Intracellular ROS in KKU-100 and KKU-213A cells after exposure to 0.75 μM Buparlisib, 0.75 μM Ponatinib and the combination of both for 6 h was measured by fluorescence microscopy using DCFH-DA staining.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Nov:180:117569. [Abstract]

    Customer Validation
     Representative image of tumors dissected from KKU-213A xenograft mice after 14 days of treatment with Buparlisib (15 mg/kg/day), Ponatinib (30 mg/kg/day) and their combination.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2023 Oct;13(10):4253-4272. [Abstract]

    Customer Validation
     BxPC-3, PANC-1 and H6c7 cells were treated with ponatinib (0.1–20 μM) for 24 h, and then cell viability was analyzed by CCK-8 assay.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2023 Oct;13(10):4253-4272. [Abstract]

    Customer Validation
     PANC-1 cells were treated with Ponatinib (5-20 μM) or Perifosine (30-70 μM) for 24 h, and total cellular extracts were subjected to Western blot analyses using antibodies against GSDMD and β-tubulin.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Exp Hematol. 2014 May;42(5):369-379.e3. [Abstract]

    Customer Validation
     Phosphorylation levels of F/P (or its mutant), STAT5, or ERK in lysates of CMPs expressing Hes1 with F/P, F/P-D842V, or F/P-T674I, which have been treated with indicated doses of Ponatinib (0.1-1 μM) for 15 min. Data are representative of three independent experiments.

  • Ponatinib hydrochloride