PROTAC BRD9 Degrader-4
Based on 1 Customer Validation
PROTAC BRD9 Degrader-4 is a BRD9 PROTAC degrader with a DC50 of 1 nM. PROTAC BRD9 Degrader-4 is applicable to research related to synovial sarcoma and acute myeloid leukemia.
(Pink: BRD9 ligand (HY-150872); Blue: Cereblon ligand (HY-W249500); Black: linker).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.06%
- CAS No.: 2633632-34-3
- Formule: C42H49FN6O7
- Masse moléculaire:768.87
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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BRD9 1 nM (DC50) |
Cereblon |
Chemical Information
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CAS No. 2633632-34-3
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Appearance Solid
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Masse moléculaire 768.87
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Formule C42H49FN6O7
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Color Off-white to light yellow
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SMILES
CCCCN1C=C(C2=CC(OC)=C(C=C2)O[C@@H]3[C@H](CN(CC3)CC4CCN(CC4)C(C5=CC(N6C(NC(CC6)=O)=O)=C(C=C5)OC)=O)F)C7=CC=NC=C7C1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
DMSO : 100 mg/mL (130.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3006 mL | 6.5030 mL | 13.0061 mL | 32.5152 mL |
| 5 mM | 0.2601 mL | 1.3006 mL | 2.6012 mL | 6.5030 mL | |
| 10 mM | 0.1301 mL | 0.6503 mL | 1.3006 mL | 3.2515 mL | |
| 15 mM | 0.0867 mL | 0.4335 mL | 0.8671 mL | 2.1677 mL | |
| 20 mM | 0.0650 mL | 0.3252 mL | 0.6503 mL | 1.6258 mL | |
| 25 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3006 mL | |
| 30 mM | 0.0434 mL | 0.2168 mL | 0.4335 mL | 1.0838 mL | |
| 40 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8129 mL | |
| 50 mM | 0.0260 mL | 0.1301 mL | 0.2601 mL | 0.6503 mL | |
| 60 mM | 0.0217 mL | 0.1084 mL | 0.2168 mL | 0.5419 mL | |
| 80 mM | 0.0163 mL | 0.0813 mL | 0.1626 mL | 0.4064 mL | |
| 100 mM | 0.0130 mL | 0.0650 mL | 0.1301 mL | 0.3252 mL |
PROTAC BRD9 Degrader-4 Related Classifications
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