1. Immunology/Inflammation
    Apoptosis
    Anti-infection
  2. Interleukin Related
    Caspase
    SARS-CoV
  3. SDZ 224-015

SDZ 224-015 

Cat. No.: HY-141622
Handling Instructions

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM).

For research use only. We do not sell to patients.

SDZ 224-015 Chemical Structure

SDZ 224-015 Chemical Structure

CAS No. : 161511-45-1

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Description

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM)[1][2].

In Vivo

SDZ 224-015 (0.3-300 μg/kg) potently reduces carrageenin-induced paw oedema[2].
SDZ 224-015 (0.2-5 mg/kg, p.o.) displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

652.52

Formula

C₃₀H₃₅Cl₂N₃O₉

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SDZ 224-015
Cat. No.:
HY-141622
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