760 Results for "

Natural compound

" in MedChemExpress (MCE) Product Catalog:
Products (760)

760 Results for "Natural compound" in MCE Product Catalog:

5
Abscisic acid
Abscisic acid
0 Images
5 Cited Publications
Cat. No.: HY-100560
CAS No.: 21293-29-8
Purity:  99.64%
Synonyms: (S)​-​(+)​-​Abscisic acid; ABA
Category:  

Metabolic Disease Plants Other Families Extract Endogenous metabolite Agricultural Research Microorganisms Animals Terpenoids Sesquiterpenes Abscisic acid Phytohormone Disease Research Fields

Target:  

Environmental Pollutants Endogenous Metabolite ABA Receptor Proton Pump

Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H +-ATPase) and leads to the plasma membrane depolarization in a Ca 2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .
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5
Isorhamnetin-3-O-glucoside
Isorhamnetin-3-O-glucoside
0 Images
5 Cited Publications
Cat. No.: HY-N0777
CAS No.: 5041-82-7
Category:  

Cruciferous vegetables Flavonols Flavonoids Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Brassicaceae Extract

Target:  

Others PERK ERK Akt PI3K Lipase

Isorhamnetin-3-O-glucoside is an orally active natural compound. Isorhamnetin 3-O-glucoside increases P-ERK, ERK, P-Akt (Ser473), P-PI3K, and PDX-1. Isorhamnetin 3-O-glucoside downregulates C/EBPα and inhibits lipase. Isorhamnetin 3-O-glucoside reduces lipids and inhibits obesity .
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5
Umbelliferone
Umbelliferone
0 Images
5 Cited Publications
Cat. No.: HY-N0573
CAS No.: 93-35-6
Synonyms: 7-Hydroxycoumarin; Hydrangin; NSC 19790
Category:  

Monophenols Coumarins Phenols Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer

Target:  

Apoptosis Fluorescent Dye

Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .
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5
Curcumenol
Curcumenol
0 Images
5 Cited Publications
Cat. No.: HY-N2259
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol
Category:  

Neurological Disease Zingiberaceae Extract Terpenoids Sesquiterpenes Plants Curcuma phaeocaulis Valeton Disease Research Fields Inflammation/Immunology Cancer

Target:  

Cytochrome P450 NF-κB MMP Interleukin Related TNF Receptor Akt p38 MAPK Ferroptosis Apoptosis CXCR COX Caspase Bcl-2 Family TGF-β Receptor

Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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4
Prostratin
Prostratin
0 Images
4 Cited Publications
Cat. No.: HY-107421
CAS No.: 60857-08-1
Purity:  99.80%
Category:  

Infection Terpenoids Diterpenoids Plants Thymelaeaceae Extract Disease Research Fields Wikstroemia chamaedaphne Meisn.

Target:  

PKC HIV

Prostratin, a natural terpenoid compound, is a PKC activator, with a Ki of 12.5 nM and shows inhibitory effect on HIV-1.
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4
Hydroxygenkwanin
Hydroxygenkwanin
0 Images
4 Cited Publications
Cat. No.: HY-N1438
CAS No.: 20243-59-8
Synonyms: 7-O-Methylluteolin
Category:  

Flavonoids Flavones Phenols Polyphenols Plants Thymelaeaceae Extract Disease Research Fields Daphne genkwa Sieb. et Zucc. Cancer

Target:  

Others

Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, is one of the main components of Lilac Daphne. Hydroxygenkwanin has anti-oxidant ability, anti-glioma ability and anticancer effect .
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4
Protocatechualdehyde
Protocatechualdehyde
0 Images
4 Cited Publications
Cat. No.: HY-N0295
CAS No.: 139-85-5
Synonyms: Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV
Category:  

Infection Anti-aging Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Cancer Labiatae Extract

Target:  

Reactive Oxygen Species (ROS) Bacterial Endogenous Metabolite

Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent .
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4
Ethyl Caffeate
Ethyl Caffeate
0 Images
4 Cited Publications
Cat. No.: HY-N6966
CAS No.: 102-37-4
Category:  

Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae Extract Disease Research Fields Inflammation/Immunology Cancer

Target:  

NF-κB NO Synthase COX PGE synthase

Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin .
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3
Sagittatoside A
Sagittatoside A
0 Images
3 Cited Publications
Cat. No.: HY-N0873
CAS No.: 118525-35-2
Synonyms: Icariin-A
Category:  

Flavonols Flavonoids Other Diseases Phenols Polyphenols Epimedium brevicornu Maxim. Plants Disease Research Fields Berberidaceae Extract

Target:  

Others

Sagittatoside A (Icariin-A) is a natural compound extracted from the plant Epimedium.
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3
Spiraeoside
Spiraeoside
0 Images
3 Cited Publications
Cat. No.: HY-N8253
CAS No.: 20229-56-5
Synonyms: Quercetin 4′-O-glucoside
Category:  

Flavonoids Flavonones Phenols Polyphenols Allium cepa L. Plants Liliaceae Extract Disease Research Fields Inflammation/Immunology

Target:  

Reactive Oxygen Species (ROS)

Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .
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3
Escin
Escin
0 Images
3 Cited Publications
Cat. No.: HY-B2114
CAS No.: 6805-41-0
Category:  

Triterpenes Hippocastanaceae Extract Terpenoids Aesculus hippocastanum Plants Saccharides

Target:  

Apoptosis

Escin, a natural compound of triterpenoid saponins that can be isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent .
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3
Indole
Indole
0 Images
3 Cited Publications
Cat. No.: HY-W001132
CAS No.: 120-72-9
Category:  

Alkaloids Human Gut Microbiota Metabolites Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields Indole Alkaloids

Target:  

Endogenous Metabolite

Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule .
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3
Cirsilineol
Cirsilineol
0 Images
3 Cited Publications
Cat. No.: HY-119347
CAS No.: 41365-32-6
Purity:  ≥98.0%
Category:  

Laburnum anagyroides Medic. Flavonoids Monophenols Flavones Phenols Plants Compositae Extract Disease Research Fields Inflammation/Immunology

Target:  

IFNAR STAT

Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 + T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .
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3
Miltirone
Miltirone
0 Images
3 Cited Publications
Cat. No.: HY-N1951
CAS No.: 27210-57-7
Synonyms: Rosmariquinone
Category:  

Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants Labiatae Extract

Target:  

GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV

Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro) .
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3
Garcinone C
Garcinone C
0 Images
3 Cited Publications
Cat. No.: HY-N6954
CAS No.: 76996-27-5
Category:  

Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Extract Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:  

ATM/ATR STAT CDK Hedgehog

Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
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3
Curcumin (Standard)
Curcumin (Standard)
0 Images
3 Cited Publications
Cat. No.: HY-N0005R
CAS No.: 458-37-7
Synonyms: Diferuloylmethane (Standard); Natural Yellow 3 (Standard); Turmeric yellow (Standard)
Category:  

Microorganisms Zingiberaceae Extract Phenols Polyphenols Plants Curcuma longa

Target:  

Reference Standards Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis

Curcumin (Standard) is the analytical standard of Curcumin (HY-N0005). This product is intended for research and analytical applications. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
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2
Coumarin-3-carboxylic Acid
Coumarin-3-carboxylic Acid
0 Images
2 Cited Publications
Cat. No.: HY-W027968
CAS No.: 531-81-7
Synonyms: 2-Oxochromene-3-carboxylic acid
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line .
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2
Methyl cinnamate
Methyl cinnamate
0 Images
2 Cited Publications
Cat. No.: HY-W017212
CAS No.: 103-26-4
Synonyms: Methyl 3-phenylpropenoate
Category:  

Rutaceae Extract Simple Phenylpropanols Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC.

Target:  

Environmental Pollutants AMPK Bacterial Tyrosinase

Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .
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2
3-Deoxysappanchalcone
3-Deoxysappanchalcone
0 Images
2 Cited Publications
Cat. No.: HY-N1745A
CAS No.: 112408-67-0
Category:  

Flavonoids Chalcones Caesalpinia sappan L. Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields Inflammation/Immunology

Target:  

Reactive Oxygen Species (ROS) Apoptosis

3-Deoxysappanchalcone is a natural chalcone compound isolated from the heartwood of Caesalpinia sappan L. 3-Deoxysappanchalcone induces cell cycle arrest, ROS production, and apoptosis. 3-Deoxysappanchalcone exhibits anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic activities. 3-Deoxysappanchalcone is applicable to research related to lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infection .
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2
Gardenoside
Gardenoside
0 Images
2 Cited Publications
Cat. No.: HY-N1478
CAS No.: 24512-62-7
Category:  

Iridoids Terpenoids Plants Gardenia jasminoides Ellis Rubiaceae Extract

Target:  

P2X Receptor Reactive Oxygen Species (ROS)

Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study .
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