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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
761 Results for "
ACHE
" in MedChemExpress (MCE) Product Catalog:
Products (761)
761 Results for "ACHE" in MCE Product Catalog:
24
24 Publications Verification
Synonyms: E2020 free base
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Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .
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Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .
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13
13 Cited Publications
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α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity .
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8 Cited Publications
Cat. No.: HY-B2244
CAS No.: 206658-92-6
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Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
8
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Tacrine hydrochloride is a potent brain-penetrant inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease .
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Tacrine is an effective oral acetylcholine (AChE) inhibitor (IC50 = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease .
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Neurological Disease Umbelliferae Extract Coumarins Phenylpropanoids Plants Helogyne apaloidea Nutt. Disease Research Fields Cancer
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6 Cited Publications
Cat. No.: HY-N0826
CAS No.: 18797-79-0
Corynoline is an orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM. Corynoline exhibits multiple activities including anti-inflammatory, antinociceptive, antitumor and analgesic effects. Corynoline can be used in the research of diseases such as tumors and inflammatory pain .
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Alkaloids Neurological Disease Anti-aging Terpenoids Huperziaceae Extract Sesquiterpenes Pyridine Alkaloids Huperzia serrata (Thunb. ex Murray) Trevis. Plants Disease Research Fields
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5 Cited Publications
Synonyms: Gelseminic acid; Chrysatropic acid
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Coumarins Leguminosae Extract Plants Monophenols Phenols Phenylpropanoids Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Rubiaceae Extract Hedyotis diffusa Willd.
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5 Cited Publications
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MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research .
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5 Cited Publications
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4 Cited Publications
Cat. No.: HY-N0226A
CAS No.: 889665-86-5
4
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Rutaceae Extract Alkaloids Quinoline Alkaloids Plants Skimmia reevesiana Fort. Disease Research Fields Inflammation/Immunology
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
