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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
78 Results for "
AhR agonist
" in MedChemExpress (MCE) Product Catalog:
Products (78)
78 Results for "AhR agonist" in MCE Product Catalog:
105
105 Publications Verification
別名: Pifithrin hydrobromide; PFTα hydrobromide
研究分野:
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
33
33 Cited Publications
別名: 6-Formylindolo[3,2-b]carbazole
Target:
研究分野:
FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.
31
31 Cited Publications
製品番号: HY-104026B
CAS 番号: 16055-80-4
21
Category:
Cardiovascular Disease Rutaceae Extract Flavonoids Flavones Plants Disease Research Fields Citrus
Target:
19
16
16 Cited Publications
別名: WBI-1001; Benvitimod; GSK2894512
Target:
研究分野:
Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice .
9
9 Cited Publications
製品番号: HY-19317
CAS 番号: 448906-42-1
Target:
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.
6
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .
3
3 Cited Publications
製品番号: HY-W028393
CAS 番号: 392-12-1
3
3 Cited Publications
Target:
研究分野:
VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14 +CD11b + monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects .
2
2 Cited Publications
別名: 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine
2
Omeprazole sulfide (Ufiprazole) is a metabolic degradation product of Omeprazole (HY-B0113). Omeprazole sulfide acts as a modulator of AhR. Omeprazole sulfide in cells with low CYP3A4 expression, functions as an AhR antagonist; however, in cells with high CYP3A4 expression, it is rapidly metabolized to Omeprazole, thereby acting as an AhR agonist. Omeprazole sulfide exhibits antibacterial activity when conjugated with silver nanoparticles (AgNPs). Omeprazole sulfide can be used in research on acid suppression and bacterial infections .
1
1 Cited Publications
製品番号: HY-W011910
CAS 番号: 2642-37-7
1
1 Cited Publications
Target:
研究分野:
AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis .
1
1 Cited Publications
Target:
研究分野:
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
製品番号: HY-W014502
CAS 番号: 13441-51-5
研究分野:
Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections .
製品番号: HY-N0586
CAS 番号: 23599-69-1
別名: (+)-Laurelliptine
Category:
Alkaloids Lauraceae Extract Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Lindera aggregata (Sims) Kosterm.
Target:
製品番号: HY-W014075
CAS 番号: 5315-79-7
製品番号: HY-W013053
CAS 番号: 53-70-3
別名: DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene
研究分野:
Dibenz[a,h]anthracene (DBA) is an orally active polycyclic aromatic hydrocarbon, a by-product of incomplete combustion of organic matter, a potent carcinogen, and an agonist of AhR. Dibenz[a,h]anthracene induces dose-dependent increases in DNA adduct formation and lacZ mutation frequency. Dibenz[a,h]anthracene upregulates St3gal5. Dibenz[a,h]anthracene can be used in cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
