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Isoforms Recommended: BMP
Results for "

BMP

" in MedChemExpress (MCE) Product Catalog:

152

Inhibitors & Agonists

2

Screening Libraries

4

Fluorescent Dyes

7

Biochemical Assay Reagents

12

Peptides

1

MCE Kits

10

Inhibitory Antibodies

24

Natural
Products

44

Recombinant Proteins

1

Isotope-Labeled Compounds

20

Antibodies

1

Click Chemistry

38

Oligonucleotides

4

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13418A
    Dorsomorphin
    Maximum Cited Publications
    754 Publications Verification

    Compound C; BML-275

    		 Organoid AMPK TGF-β Receptor Autophagy Cancer
    Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) .
    Dorsomorphin
  • HY-13418
    Dorsomorphin dihydrochloride
    Maximum Cited Publications
    754 Publications Verification

    Compound C dihydrochloride; BML-275 dihydrochloride

    		 Organoid AMPK TGF-β Receptor Autophagy Cancer
    Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).
    Dorsomorphin dihydrochloride
  • HY-12071
    LDN193189
    80+ Cited Publications

    DM-3189

    		 Organoid TGF-β Receptor Cancer
    LDN193189 (DM-3189) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
    LDN193189
  • HY-12071B
    LDN193189 dihydrochloride
    80+ Cited Publications

    DM-3189 dihydrochloride

    		 Organoid TGF-β Receptor Cancer
    LDN193189 (DM-3189) dihydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
    LDN193189 dihydrochloride
  • HY-124697
    BMP signaling agonist sb4
    5+ Cited Publications

    		 TGF-β Receptor Cancer
    BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding,?Id1?and?Id3) canonical BMP signaling .
    BMP signaling agonist sb4
  • HY-12071A
    LDN193189 Tetrahydrochloride
    80+ Cited Publications

    DM-3189 Tetrahydrochloride

    		 Organoid TGF-β Receptor Cancer
    LDN193189 (DM-3189) Tetrahydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
    LDN193189 Tetrahydrochloride
  • HY-42146
    BMPS

    		ADC Linker Cancer
    BMPS is a nonclaevable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    BMPS
  • HY-P99643
    Ginisortamab

    UCB6114

    		 Dan family Cancer
    Ginisortamab (UCB6114) is a fully human IgG4P anti Gremlin-1 monoclonal antibody, with mean IC50 values of 8.2 nM and 9 nM against human and mouse gremlin-1, respectivly. Ginisortamab inhibits gremlin-1 antagonism of BMP signaling pathways. Ginisortamab has the potential for the research of gastrointestinal (GI) tumors .
    Ginisortamab
  • HY-N0123
    Aloin-A
    Maximum Cited Publications
    8 Publications Verification

    Barbaloin-A

    		 Wnt Cancer
    Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .
    Aloin-A
  • HY-15897
    LDN-212854
    1 Publications Verification

    		 TGF-β Receptor Cancer
    LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC50: 1.3 nM). LDN-212854 also inhibits ALK1 (IC50: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC) .
    LDN-212854
  • HY-13102
    UK-383367

    		Procollagen C Proteinase Others
    UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring .
    UK-383367
  • HY-164145
    CDD-1653

    		TGF-β Receptor Others Cancer
    CDD-1653 is a potent and selective BMPR2 inhibitor (IC50=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway .
    CDD-1653
  • HY-12071G
    LDN193189

    DM-3189

    		 Organoid TGF-β Receptor Cancer
    LDN193189 GMP is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 (DM-3189) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
    LDN193189
  • HY-112331
    SJ000291942
    3 Publications Verification

    		 TGF-β Receptor Cancer
    SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules.
    SJ000291942
  • HY-P99359
    Elezanumab

    ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)

    		 TGF-beta/Smad Metabolic Disease
    Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .
    Elezanumab
  • HY-148234
    M4K2234

    		Anaplastic lymphoma kinase (ALK) TGF-beta/Smad Cancer
    M4K2234, a chemical probe, is an orally active, highly selective inhibitor of ALK1 and ALK2 with IC50 values of 7 nM and 14 nM, respectively. M4K2234 specifically blocks BMP signaling by inhibiting the phosphorylation of SMAD1/5/8. M4K2234 inhibits BMP7-stimulated reporter gene activity (IC50 = 16 nM). M4K2234 can be used for the investigation of ALK1/2-mediated biological processes and related diseases such as diffuse midline glioma (DMG) and fibrodysplasia ossificans progressiva (FOP) .
    M4K2234
  • HY-P5832
    BMP2-derived peptide

    		TGF-beta/Smad RUNX Metabolic Disease
    BMP2-derived peptide is an osteogenic inducer and BMP receptor ligand. BMP2-derived peptide binds to BMP receptors on the cell surface to form a complex, activates the downstream Smad signaling pathway, and regulates the expression of osteogenic transcription factors. BMP2-derived peptide effectively promotes the adhesion, proliferation, osteogenic differentiation and mineralization of bone marrow mesenchymal stem cells, significantly up-regulates the mRNA levels of OCN, Runx2 and type I collagen, and increases alkaline phosphatase activity and calcium deposition. BMP2-derived peptide induces osteoblast differentiation and ectopic bone regeneration, and improves cranial bone defect repair. Meanwhile, BMP2-derived peptide enhances the cytocompatibility of mesoporous silica nanoparticles, synergistically increases osteogenic activity with Dexamethasone (HY-14648), serving as an important tool for bone defect repair research .
    BMP2-derived peptide
  • HY-P10710
    BMP-4 (15-24)

    		IFNAR Interleukin Related COX NO Synthase Inflammation/Immunology
    BMP-4 (15-24) is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) can be used in the research of arthritis .
    BMP-4 (15-24)
  • HY-147372
    SJ000063181

    		TGF-beta/Smad Metabolic Disease
    SJ000063181 is a potent BMP signaling activator. SJ000063181 activates BMP4 and the phosphorylation of SMAD1/5/8 (p-SMAD1/5/8). SJ000063181 induces ventralization in zebrafish embryos .
    SJ000063181
  • HY-123900
    AZ12799734

    		TGF-β Receptor Cardiovascular Disease
    AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC50 of 47 nM. AZ12799734 is also a pan BMP and TGFβ inhibitor .
    AZ12799734
  • HY-150793
    SY-LB-57

    		TGF-β Receptor Cardiovascular Disease Neurological Disease
    SY-LB-57 is a highly potent bone morphogenetic protein (BMP) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension .
    SY-LB-57
  • HY-150795
    SY-LB-35

    		TGF-beta/Smad PI3K Akt ERK JNK Others
    SY-LB-35 is a potent bone morphogenetic protein (BMP) receptor agonist. SY-LB-35 can stimulate significant increases in cell number and cell viability in the C2C12 myoblast cell line, and causes shifts towards the S and G2/M phases of the cell cycle. SY-LB-35 stimulates canonical Smad and non-canonical PI3K/Akt, ERK, p38 and JNK intracellular signaling pathways .
    SY-LB-35
  • HY-12071C
    LDN193189 hydrochloride
    70+ Cited Publications

    DM-3189 hydrochloride

    		 Organoid TGF-β Receptor Cancer
    LDN193189 (DM-3189) hydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
    LDN193189 hydrochloride
  • HY-107245
    Segetalin B
    2 Publications Verification

    		 Estrogen Receptor/ERR Sirtuin RUNX Metabolic Disease
    Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .
    Segetalin B
  • HY-P10710A
    BMP-4 (15-24) acetate
    1 Publications Verification

    		 IFNAR Interleukin Related COX NO Synthase Inflammation/Immunology
    BMP-4 (15-24) acetate is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) acetate exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) acetate can be used in the research of arthritis .
    BMP-4 (15-24) acetate
  • HY-N16011
    18:1 BMP (S,S) ammonium
    1 Publications Verification

    18:1 LBPA (S,S)

    		 Biochemical Assay Reagents Others
    18:1 BMP (S,S) ammonium is a bis(monoacylglycero)phosphate (BMP).
    18:1 BMP (S,S) ammonium
  • HY-N8920
    Syringetin

    		Others Metabolic Disease
    Syringetin, a flavonoid derivative, is associated with increased BMP-2 production. Syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts .
    Syringetin
  • HY-18961
    PD 407824

    		Checkpoint Kinase (Chk) Wee1 Inflammation/Immunology Cancer
    PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4 .
    PD 407824
  • HY-12273G
    DMH-1

    		Organoid TGF-β Receptor Microtubule/Tubulin Cardiovascular Disease Neurological Disease
    DMH-1 (GMP) is GMP grade DMH-1 (HY-12273). DMH-1 (GMP) is a selective BMP inhibitor. DMH-1 (GMP) upregulates the expression of SOX1. DMH-1 (GMP) increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 (GMP) induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons .
    DMH-1
  • HY-135871
    BMT-124110

    		AAK1 Neurological Disease
    BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively .
    BMT-124110
  • HY-158203
    BMP agonist 2

    		TGF-β Receptor Others
    BMP agonist 2 (derivative I-9) is a potent bone-inducing cytokine. BMP agonist 2 promotes bone tissue production by increasing the proportion and activity of osteoblasts. BMP agonist 2 promotes osteoblast proliferation and differentiation through the BMP2-ATF4 signaling axis, in which ATF4 is a transcription factor closely related to osteoblast differentiation and bone formation. BMP agonist 2 can be used in the study of senile osteoporosis (SOP) .
    BMP agonist 2
  • HY-174416
    Smurf1-IN-5

    		E1/E2/E3 Enzyme Cardiovascular Disease
    Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH) .
    Smurf1-IN-5
  • HY-162653
    SGC-CDKL2/AAK1/BMP2K-1

    		Others
    SGC-CDKL2/AAK1/BMP2K-1 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. SGC-CDKL2/AAK1/BMP2K-1 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases .
    SGC-CDKL2/AAK1/BMP2K-1
  • HY-155705
    BMP agonist 1

    		TGF-β Receptor GSK-3 β-catenin Others
    BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research .
    BMP agonist 1
  • HY-N8261
    Amicoumacin B

    		Bacterial TGF-beta/Smad Infection
    Amicoumacin B can be produced by actinomycete, strain 04-5195 T.. Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP-2). Amicoumacin B has inhibitory effect against C. violaceum (MIC = 250 µg/mL). Amicoumacin B has quorum sensing inhibitory activity, and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC .
    Amicoumacin B
  • HY-201672
    18:1 BMP (S,R) ammonium

    		Biochemical Assay Reagents Others
    18:1 BMP (S,R) ammonium is a bis(monoacylglycero)phosphate (BMP) .
    18:1 BMP (S,R) ammonium
  • HY-RS01533
    BMP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    BMP1 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BMP1 Human Pre-designed siRNA Set A
    BMP1 Human Pre-designed siRNA Set A
  • HY-RS17130
    Bmp2k Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Bmp2k Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmp2k gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Bmp2k Mouse Pre-designed siRNA Set A
    Bmp2k Mouse Pre-designed siRNA Set A
  • HY-N4019
    Maohuoside A

    		TGF-β Receptor Metabolic Disease
    Maohuoside A, a single compound isolated from the E. koreanum that potently promotes osteogenesis. Maohuoside A enhances the osteogenesis of bone marrow-derived mesenchymal stem cells via bone morphogenetic protein (BMP) and MAPK signaling pathways .
    Maohuoside A
  • HY-N0123R
    Aloin-A (Standard)

    Barbaloin-A (Standard)

    		 Reference Standards Wnt Cancer
    Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .
    Aloin-A (Standard)
  • HY-N2682B
    Dehydrodiconiferyl alcohol

    		Estrogen Receptor/ERR Metabolic Disease Inflammation/Immunology
    Dehydrodiconiferyl alcohol is an estrogen receptor agonist that can promote BMP-2-induced osteoblastogenesis. Dehydrodiconiferyl alcohol also exerts anti-inflammatory activity through inactivation of NF-κB pathways .
    Dehydrodiconiferyl alcohol
  • HY-12071BR
    LDN193189 dihydrochloride (Standard)

    DM-3189 dihydrochloride (Standard)

    		 Reference Standards Organoid TGF-β Receptor Cancer
    LDN193189 (DM-3189) dihydrochloride (Standard) is the analytical standard of LDN193189 dihydrochloride (HY-12071B). This product is intended for research and analytical applications. LDN193189 (DM-3189) dihydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
    LDN193189 dihydrochloride (Standard)
  • HY-N15968
    14:0 Hemi BMP (S,R) ammonium

    		Biochemical Assay Reagents Others
    14:0 Hemi BMP (S,R) ammonium is a bis(monoacylglycero)phosphate (BMP).
    14:0 Hemi BMP (S,R) ammonium
  • HY-N15816
    18:1 BMP (R,R'; 2,2'-isomer) ammonium

    		Biochemical Assay Reagents Others
    18:1 BMP (R,R'; 2,2'-isomer) ammonium is a bis(monoacylglycero)phosphate (BMP).
    18:1 BMP (R,R'; 2,2'-isomer) ammonium
  • HY-171248
    CDD-1115

    		Anaplastic lymphoma kinase (ALK) Cardiovascular Disease Endocrinology
    CDD-1115 is a potent, selective inhibitor of BMPR2 with IC50 of 1.8 nM, Kiapp of 6.2 nM. CDD-1115 inhibits bone morphogenetic protein (BMP)-mediated gene expression. BMP controls cellular processes across many tissue types, including the kidney, skeletal muscle, heart, and reproductive organs. BMP induces ectopic bone formation .
    CDD-1115
  • HY-167580
    18:1 Hemi BMP (S,R)

    		Biochemical Assay Reagents
    18:1 Hemi BMP (S,R) is a kind of biochemical reagent.
    18:1 Hemi BMP (S,R)
  • HY-RS24417
    Bmp6 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Bmp6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bmp6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Bmp6 Rat Pre-designed siRNA Set A
    Bmp6 Rat Pre-designed siRNA Set A
  • HY-RS17049
    Bmp7 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Bmp7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmp7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Bmp7 Mouse Pre-designed siRNA Set A
    Bmp7 Mouse Pre-designed siRNA Set A
  • HY-RS01535
    BMP15 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    BMP15 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BMP15 Human Pre-designed siRNA Set A
    BMP15 Human Pre-designed siRNA Set A
  • HY-RS19176
    Bmp15 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Bmp15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmp15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Bmp15 Mouse Pre-designed siRNA Set A
    Bmp15 Mouse Pre-designed siRNA Set A

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