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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10024 Results for "
Inflammation
" in MedChemExpress (MCE) Product Catalog:
Products (10024)
10024 Results for "Inflammation" in MCE Product Catalog:
679
679 Publications Verification
Referencia número: HY-D1056
Synonyms: LPS, from Escherichia coli (O55:B5)
Target:
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
522
522 Cited Publications
Synonyms: CP-456773; CRID3
Target:
Áreas de investigación:
MCC950 (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
522
522 Cited Publications
Synonyms: CP-456773 sodium; CRID3 sodium salt
Target:
Áreas de investigación:
MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
228
228 Cited Publications
Synonyms: 1,1-Dimethylbiguanide hydrochloride
Áreas de investigación:
Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
228
228 Cited Publications
Synonyms: 1,1-Dimethylbiguanide
Áreas de investigación:
Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
197
197 Cited Publications
Target:
Áreas de investigación:
H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease .
188
188 Cited Publications
Synonyms: VX-765
Target:
Áreas de investigación:
Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
184
184 Cited Publications
Synonyms: Adenosine 5'-triphosphate
184
184 Cited Publications
Referencia número: HY-B2176B
No. CAS: 74804-12-9
Synonyms: Adenosine 5'-triphosphate dimagnesium
184
184 Cited Publications
Referencia número: HY-B2176A
No. CAS: 51963-61-2
Synonyms: Adenosine-5'-triphosphate disodium trihydrate
181
181 Cited Publications
Synonyms: Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate
Category:
Natural Products Plant Animal Other Families Extract Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
177
177 Cited Publications
Referencia número: HY-W010735
No. CAS: 34369-07-8
Synonyms: Adenosine 5'-triphosphate disodium salt hydrate
174
174 Cited Publications
Referencia número: HY-B2176C
No. CAS: 42373-41-1
Synonyms: Adenosine 5'-triphosphate dipotassium
174
174 Cited Publications
Synonyms: Adenosine 5'-triphosphate magnesium
Áreas de investigación:
ATP (Adenosine 5'-triphosphate) magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP magnesium is an important endogenous signaling molecule in immunity and inflammation. ATP magnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP magnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
174
174 Cited Publications
Synonyms: Adenosine 5'-triphosphate disodium salt, 100 mM Solution, PCR Grade
Áreas de investigación:
ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
156
156 Cited Publications
Referencia número: HY-A0190
No. CAS: 17650-98-5
Synonyms: Ceruletide; Cerulein; FI-6934
Category:
Cardiovascular Disease Alkaloids Animal Disease Research Fields Endocrinology Indole Alkaloids
Target:
138
138 Cited Publications
Target:
Áreas de investigación:
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING .
126
126 Cited Publications
Target:
Áreas de investigación:
C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively .
125
125 Cited Publications
Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride
Áreas de investigación:
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na +/H +-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .
125
125 Cited Publications
Synonyms: L593754; MH 12-43; Ethylisopropylamiloride
Áreas de investigación:
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na +/H +-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
