Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
MITF
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "MITF" in MCE Product Catalog:
7
7 Publications Verification
Research Areas:
ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM.
2
2 Cited Publications
Research Areas:
TT-012 is a MITF inhibitor with a human MITF IC50 of 13.1 nM and a human MITF Kd value of 15.5 nM. TT-012 reduces mRNA levels of MITF downstream genes linked to melanosome biogenesis, cell survival, and proliferation, and upregulates cell cycle-inhibiting genes. TT-012 can be used for the research of melanoma[1][2][3].
1
Cat. No.: HY-113337A
CAS No.: 102783-36-8
Synonyms: P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium
Ap4A tetraammonium (P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis .
Category:
Microorganisms Other Diseases Phenols Polyphenols Plants Ericaceae Disease Research Fields
Target:
Target:
Cat. No.: HY-N2413
CAS No.: 60546-10-3
Cat. No.: HY-N2983
CAS No.: 32884-36-9
Category:
Flavonoids Leguminosae Other Diseases Phenols Polyphenols Red seaweeds Plants Disease Research Fields Isoflavones
Target:
Cat. No.: HY-N6901
CAS No.: 56857-57-9
Category:
other families Flavonoids Flavones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields
Target:
Synonyms: 7-Desacetoxy-6,7-dehydrogedunin
Target:
PERK Prokineticin Receptor P2X Receptor Caspase NOD-like Receptor (NLR) Pyroptosis Tyrosinase
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, P2X7 purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP-catalytic domain of PKR, blocks the kinase activity-independent protein-protein interactions of PKR, inhibits the phosphorylation and activity of PKR, disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis, suppresses the ATP-P2X7 signaling pathway, and abolishes ATP-induced increases in the expression levels of MITF, tyrosinase, PMEL/gp100, and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders .
Cat. No.: HY-N10016
CAS No.: 132741-56-1
Target:
Cat. No.: HY-N12267
CAS No.: 42369-86-8
Synonyms: (E/Z)-Terrestribisamide
Category:
Target:
Target:
Cat. No.: HY-RS16290
Target:
Research Areas:
Mitf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mitf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-179717
Research Areas:
WZS0347 is a MITF PROTAC degrader. WZS0347 effectively reduces the MITF protein levels in several melanoma cell lines, including B16F10, A375, and GAK. WZS0347 significantly inhibits the proliferation, migration, and invasion of melanoma cells. WZS0347 can be used for research on melanoma .
Cat. No.: HY-179718
Research Areas:
TT-012-Br (Compound 4) is a ligand for MITF and can be used for the synthesis of PROTACs, such as WZS0347 (HY-179717) .
Cat. No.: HY-N10623
CAS No.: 2767066-84-0
Category:
Terpenoids Sesquiterpenes Plants Compositae Seriphidium transiliense Disease Research Fields Cancer
Target:
Cat. No.: HY-174580
Human MITF mRNA encodes the human melanocyte inducing transcription factor (MITF) protein, a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. MITF could regulate melanocyte development and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
