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Results for "

MITF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microphthalmia Associated Transcription Factor (MITF) (4) Akt (1) Antibiotic (1) Apoptosis (4) AUTACs (1) Autophagy (2) Caspase (1) COX (1) Environmental Pollutants (1) Epigenetic Reader Domain (1) ERK (3) Fluorescent Dye (1) Glutathione Peroxidase (1) Interleukin Related (2) Keap1-Nrf2 (1) Ligands for Target Protein for PROTAC (1) Melanocortin Receptor (1) Microtubule/Tubulin (1) mRNA (1) Na+/K+ ATPase (1) NF-κB (1) NOD-like Receptor (NLR) (1) P2X Receptor (1) p38 MAPK (3) PARP (1) PD-1/PD-L1 (1) PDGFR (1) PERK (1) PKA (1) Prokineticin Receptor (1) PROTACs (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (3) Reference Standards (2) Small Interfering RNA (siRNA) (4) Target Protein Ligand-Linker Conjugates (1) Tyrosinase (15) UGT (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Inflammation/Immunology (6) Metabolic Disease (9) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Transcription Factors (1) mRNA (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Microphthalmia Associated Transcription Factor (MITF)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101464

ML329 Maximum Cited Publications 7 Publications Verification	Microphthalmia Associated Transcription Factor (MITF)	Others
ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC₅₀ of 1.2 μM.

HY-113337A

Ap4A tetraammonium P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium	Apoptosis	Cancer
Ap4A tetraammonium (P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis .

HY-D0168

Orcinol 3,5-Dihydroxytoluene	Fluorescent Dye Tyrosinase p38 MAPK ERK	Metabolic Disease Cancer
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of *MITF, tyrosinase (TYR), TRP1, and DCT*. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

HY-N1481

Methyl linoleate	Environmental Pollutants Tyrosinase	Metabolic Disease
Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins .

HY-N2413

Gomisin D	PDGFR UGT Reactive Oxygen Species (ROS) Apoptosis Tyrosinase p38 MAPK Akt ERK COX Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology
Gomisin D is an orally active lignan that binds to PDGFRβ with a K_d of 10 μM. By targeting PDGFRβ to regulate signaling pathways, Gomisin D inhibits the activation and proliferation of hepatic stellate cells and promotes their apoptosis, thereby ameliorating hepatic fibrosis. Gomisin D exhibits multiple activities such as photoprotection, antimelanogenesis, antioxidant effects, and hypoglycemic activity. Gomisin D can be used in studies related to diabetes, Alzheimer's disease, and hepatic fibrosis .

HY-156483

TT-012 2 Publications Verification	Microphthalmia Associated Transcription Factor (MITF)	Cancer
TT-012 is a *MITF* inhibitor with a human MITF IC₅₀ of 13.1 nM and a human MITF K_d value of 15.5 nM. TT-012 reduces mRNA levels of MITF downstream genes linked to melanosome biogenesis, cell survival, and proliferation, and upregulates cell cycle-inhibiting genes. TT-012 can be used for the research of melanoma^[1]^[2]^[3].

HY-N2983

Cajanin	Tyrosinase	Others
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis .

HY-N2204

Swertiajaponin	Tyrosinase Reactive Oxygen Species (ROS)	Inflammation/Immunology
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP	Tyrosinase Reactive Oxygen Species (ROS) Keap1-Nrf2 PARP Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
3',4'-Dihydroxyacetophenone (3,4-DHAP) is a phenolic compound with oral bioavailability, possessing potent antioxidant, anti-inflammatory, anticancer and cardiovascular protective activities. 3',4'-Dihydroxyacetophenone inhibits mushroom Tyrosinase activity with an IC₅₀ of 10 μM, thereby suppressing melanogenesis . 3',4'-Dihydroxyacetophenone inhibits platelet aggregation in platelet-rich plasma. 3',4'-Dihydroxyacetophenone reduces ROS levels in human umbilical vein endothelial cells treated with high glucose, upregulates the expression of Nrf2, HO-1 and PARP-1 in cells, and promotes the nuclear translocation of Nrf2 . 3',4'-Dihydroxyacetophenone induces autophagy and apoptosis. 3',4'-Dihydroxyacetophenone inhibits seed germination/growth in most plants. 3',4'-Dihydroxyacetophenone can be used in the research of cancer, neurodegenerative diseases, non-alcoholic steatohepatitis, diabetes, obesity, skin pigmentation disorders, and cardiovascular and cerebrovascular diseases .

HY-N6901

Luteolin 7-sulfate	Epigenetic Reader Domain	Metabolic Disease
Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis .

HY-124857

7DG 7-Desacetoxy-6,7-dehydrogedunin	PERK Prokineticin Receptor P2X Receptor Caspase NOD-like Receptor (NLR) Pyroptosis Tyrosinase	Neurological Disease Metabolic Disease Inflammation/Immunology
7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, P2X7 purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP-catalytic domain of PKR, blocks the kinase activity-independent protein-protein interactions of PKR, inhibits the phosphorylation and activity of PKR, disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis, suppresses the ATP-P2X7 signaling pathway, and abolishes ATP-induced increases in the expression levels of *MITF, tyrosinase, PMEL/gp100*, and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders .

HY-N10016

Chlorogenic acid butyl ester	Tyrosinase	Cancer
Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2. Chlorogenic acid butyl ester also shows antioxidant activity .

HY-N12267

N,N′-Diferuloylputrescine (E/Z)-Terrestribisamide	Melanocortin Receptor	Metabolic Disease
N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is a inhibitor of pigmentation with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species .

HY-113337

Ap4A P1,P4-Di-(adenosine-5')-tetraphosphate	Apoptosis	Cancer
Ap4A (P1,P4-Di-(adenosine-5')-tetraphosphate) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A induces apoptosis .

HY-RS16290

Mitf Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Cancer
Mitf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mitf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mitf Mouse Pre-designed siRNA Set A Mitf Mouse Pre-designed siRNA Set A

HY-179717

WZS0347	PROTACs Microphthalmia Associated Transcription Factor (MITF)	Cancer
WZS0347 is a MITF PROTAC degrader. WZS0347 effectively reduces the MITF protein levels in several melanoma cell lines, including B16F10, A375, and GAK. WZS0347 significantly inhibits the proliferation, migration, and invasion of melanoma cells. WZS0347 can be used for research on melanoma (Pink: MITF ligand: (HY-179718); Blue: CRBN ligand: (HY-131717); Black: linker: (HY-22391)) .

HY-179718

TT-012-Br	Ligands for Target Protein for PROTAC Microphthalmia Associated Transcription Factor (MITF)	Cancer
TT-012-Br (Compound 4) is a ligand for *MITF* and can be used for the synthesis of PROTACs, such as WZS0347 (HY-179717) .

HY-N10623

5-epi-Arvestonate A	Tyrosinase	Cancer
5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells .

HY-174580

*Human MITF* mRNA**	mRNA	Cancer
Human MITF mRNA encodes the human melanocyte inducing transcription factor (MITF) protein, a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. MITF could regulate melanocyte development and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes.

HY-169363

PDL1 degrader-2	PD-1/PD-L1 Autophagy AUTACs	Cancer
PD-L1 degrader-2 (Compound B3) is an orally active AUTAC degrader, that degrades PD-L1 through autophagy-lysosome pathway with a DC₅₀ of 0.5 μM. PD-L1 degrader-2 exhibits inhibitory activity against PD-1/PD-L1 interaction with an IC₅₀ of 22.8 nM. PD-L1 degrader-2 upregulates the expressions of Atg9b, Lamp1 and Mitf, and activates the autophagy lysosome system. PD-L1 degrader- exhibits antitumor efficacy in CT26 mouse model . (Pink: autophagy-lysosome activator (HY-159894); Black: linker (HY-W015088); Blue: PD-L1 ligand (HY-169365))

HY-N4280

7,8-Dimethoxycoumarin 1 Publications Verification	Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology
7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H ⁺/K ⁺-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .

HY-RS08467

MITF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MITF Human Pre-designed siRNA Set A contains three designed siRNAs for MITF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MITF Human Pre-designed siRNA Set A MITF Human Pre-designed siRNA Set A

HY-RS23266

Mitf Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mitf Rat Pre-designed siRNA Set A contains three designed siRNAs for Mitf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mitf Rat Pre-designed siRNA Set A Mitf Rat Pre-designed siRNA Set A

HY-N1481R

Methyl linoleate (Standard)	Tyrosinase Reference Standards	Metabolic Disease
Methyl linoleate (Standard) is the analytical standard of Methyl linoleate. This product is intended for research and analytical applications. Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins .

HY-N10437

6-Acetylnimbandiol 6-O-Acetylnimbandiol	Tyrosinase	Cancer
6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC₅₀=69.85 μM) that effectively inhibits melanin production and *MITF* expression. 6-Acetylnimbandiol can be used in melanoma research .

HY-N3810

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Tyrosinase	Others
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

HY-P4497

Prolylserine	ERK	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB) .

HY-157010

AP736	Tyrosinase PKA	Others
AP736 is a potent tyrosinase inhibitor (IC₅₀ = 0.9 μM) with anti-melanogenesis activity in normal human melanocytes (IC₅₀ = 0.11 μM). AP736 suppresses the expression of tyrosinase and TRP-1/2 by inhibiting the cAMP-PKA-CREB signalling axis, leading to reduced microphthalmia-associated transcription factor (MITF) transcripts and proteins. AP736 can be used for melanogenesis and hyperpigmentation research .

HY-159917

PPL agonist-1	Tyrosinase Microtubule/Tubulin	Inflammation/Immunology
PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing *MITF* expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment .

HY-N0113A

Hordenine sulfate Ordenina sulfate; Peyocactine sulfate	Antibiotic	Others
Hordenine sulfate (Ordenina sulfate) is an active compound extracted from malted barley that has melanin-inhibiting activity. Hordenine sulfate significantly reduced melanin content and reduced intracellular cAMP levels. Hordenine sulfate inhibits the expression of proteins related to melanogenesis, including microblind transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, Hordenine sulfate can be used as an active ingredient to inhibit pigmentation .

HY-RS17594

Tff3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tff3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tff3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tff3 Mouse Pre-designed siRNA Set A Tff3 Mouse Pre-designed siRNA Set A

HY-101464R

ML329 (Standard)	Others Reference Standards	Others
ML329 (Standard) is the analytical standard of ML329 (HY-101464). This product is intended for research and analytical applications. ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM.

HY-179720

TT-012-NH-C7-NHBoc	Target Protein Ligand-Linker Conjugates	Cancer
WZS0347 Ligand-Linker Conjugate 1 (Compound 5d) is a synthetic target protein ligand-linker conjugate, which can be used for the synthesis of PROTACs, such as WZS0347 (HY-179717). WZS0347 is a potent MITF PROTAC degrader with anti-cancer activity .

HY-N17896

Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside	Tyrosinase	Cancer
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is a lignan compound and a melanogenesis inhibitor with low cytotoxicity. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is isolable from the stem bark of Acer buergerianum (Acer buergerianum). Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside effectively inhibits the melanogenesis process in α-MSH (HY-P0252)-stimulated B16 melanoma cells. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside exhibits extremely high safety towards normal cells, and serves as an ideal tool molecule for studying melanoma mechanisms and developing related whitening products .

Cat. No.	Product Name	Type

HY-D0168

Orcinol 3,5-Dihydroxytoluene	Fluorescent Dye
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of *MITF, tyrosinase (TYR), TRP1, and DCT*. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

Orcinol

3,5-Dihydroxytoluene

Fluorescent Dye

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

Cat. No.	Product Name	Target	Research Area

HY-P4497

Prolylserine	ERK	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB) .

Orcinol 3,5-Dihydroxytoluene	Microorganisms Classification of Application Fields Other Diseases Phenols Polyphenols Ericaceae Plants Disease Research Fields Source Classification	Fluorescent Dye Tyrosinase p38 MAPK ERK
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of *MITF, tyrosinase (TYR), TRP1, and DCT*. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

Methyl linoleate	Structural Classification other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Lipid Source Classification	Environmental Pollutants Tyrosinase
Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins .

Gomisin D	Structural Classification Classification of Application Fields Lignans Metabolic Disease Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Source Classification	PDGFR UGT Reactive Oxygen Species (ROS) Apoptosis Tyrosinase p38 MAPK Akt ERK COX Interleukin Related
Gomisin D is an orally active lignan that binds to PDGFRβ with a K_d of 10 μM. By targeting PDGFRβ to regulate signaling pathways, Gomisin D inhibits the activation and proliferation of hepatic stellate cells and promotes their apoptosis, thereby ameliorating hepatic fibrosis. Gomisin D exhibits multiple activities such as photoprotection, antimelanogenesis, antioxidant effects, and hypoglycemic activity. Gomisin D can be used in studies related to diabetes, Alzheimer's disease, and hepatic fibrosis .

Cajanin	Flavonoids Classification of Application Fields Leguminosae Other Diseases Phenols Polyphenols Red seaweeds Plants Disease Research Fields Isoflavones Source Classification	Tyrosinase
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis .

Swertiajaponin	Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase Reactive Oxygen Species (ROS)
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .

3',4'-Dihydroxyacetophenone 3,4-DHAP	Structural Classification Classification of Application Fields Pinaceae Phenols Polyphenols Picea schrenkiana Fisch. et Mey. Plants Disease Research Fields Source Classification Cancer	Tyrosinase Reactive Oxygen Species (ROS) Keap1-Nrf2 PARP Autophagy Apoptosis
3',4'-Dihydroxyacetophenone (3,4-DHAP) is a phenolic compound with oral bioavailability, possessing potent antioxidant, anti-inflammatory, anticancer and cardiovascular protective activities. 3',4'-Dihydroxyacetophenone inhibits mushroom Tyrosinase activity with an IC₅₀ of 10 μM, thereby suppressing melanogenesis . 3',4'-Dihydroxyacetophenone inhibits platelet aggregation in platelet-rich plasma. 3',4'-Dihydroxyacetophenone reduces ROS levels in human umbilical vein endothelial cells treated with high glucose, upregulates the expression of Nrf2, HO-1 and PARP-1 in cells, and promotes the nuclear translocation of Nrf2 . 3',4'-Dihydroxyacetophenone induces autophagy and apoptosis. 3',4'-Dihydroxyacetophenone inhibits seed germination/growth in most plants. 3',4'-Dihydroxyacetophenone can be used in the research of cancer, neurodegenerative diseases, non-alcoholic steatohepatitis, diabetes, obesity, skin pigmentation disorders, and cardiovascular and cerebrovascular diseases .

Luteolin 7-sulfate	Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	Epigenetic Reader Domain
Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71356

	TFF3 Protein, Mouse (HEK293, His) Trefoil factor 3; Intestinal trefoil factor; MITF; Tff3; Itf	Mouse	HEK293
	TFF3 Protein maintains and repairs the intestinal mucosa, promoting epithelial cell mobility as a motogen.TFF3's monomer form has functional properties, while its homodimeric form enhances cellular responses for intestinal lining integrity.TFF3's involvement in mucosal homeostasis and repair highlights its significance in gastrointestinal tract dynamics.TFF3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TFF3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74529

	TFF3 Protein, Human (HEK293, His) Trefoil factor 3; Intestinal trefoil factor; MITF; Tff3; Itf	Human	HEK293
	Trefoil factor 3 (TFF3) is a small peptide (59 amino acids; 7 kDa) that is a member of the trefoil family and a stable secretory protein expressed in gastrointestinal mucosa, playing a role in restitution and regeneration of epithelia. The mode of action of Tff3 ranges from a simple increase in mucous viscosity, cytoprotection, and antiapoptotic and chemotactic effects to more complex immune regulatory functions, and has a strong association with tumorigenesis. TFF3 Protein, Human (HEK293, His) is the recombinant human-derived TFF3 protein, expressed by HEK293 , with C-His labeled tag.

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Host:	Mouse (2) Rabbit (4)
Reactivity:	Human (6) Rat (2) Mouse (2)
Application:	IHC-P (3) ICC/IF (2) IP (1) WB (4) FC (3) ELISA (3)
Isotype:	IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86614

	MiTF Antibody (YA6306) MITF; BHLHE32; Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; bHLHe32	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MiTF Antibody (YA6306) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MiTF.

HY-P80225

	MiTF Antibody (YA292)	WB, ICC/IF, FC	Human, Mouse, Rat
	MiTF Antibody (YA292) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MiTF.

HY-P81497

	Trefoil Factor 3 Antibody (YA1242) hITF; hP1.B; InTinal trefoil factor; ITF; MITF; P1B; Polypeptide P1.B; TFF3; TFI; TREFOIL; Trefoil factor 3	IHC-P	Human
	Trefoil Factor 3 Antibody (YA1242) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Trefoil Factor 3.

HY-P81497A

	Trefoil Factor 3 Antibody (YA1242)(PBS only) hITF; hP1.B; InTinal trefoil factor; ITF; MITF; P1B; Polypeptide P1.B; TFF3; TFI; TREFOIL; Trefoil factor 3	IHC-P	Human
	Trefoil Factor 3 Antibody (YA1242) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Trefoil Factor 3.

HY-P83855

	MITF Antibody (YA3552) MI; WS2; CMM8; WS2A; bHLHe32	WB, FC, ELISA	Human
	MITF Antibody (YA3552) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MITF.

HY-P83855A

	MITF Antibody (YA3552)(PBS only) MI; WS2; CMM8; WS2A; bHLHe32	WB, FC, ELISA	Human
	MITF Antibody (YA3552) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MITF.

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Cat. No.	Product Name		Classification

HY-174580

*Human MITF* mRNA**		mRNA Transcription Factors
Human MITF mRNA encodes the human melanocyte inducing transcription factor (MITF) protein, a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. MITF could regulate melanocyte development and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes.

HY-RS08467

MITF Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MITF Human Pre-designed siRNA Set A contains three designed siRNAs for MITF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23266

Mitf Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Mitf Rat Pre-designed siRNA Set A contains three designed siRNAs for Mitf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17594

Tff3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tff3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tff3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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