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Results for "

MiT/TFE family members

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MicroRNA (4) 5 alpha Reductase (1) 5-HT Receptor (8) AAK1 (2) Acetolactate Synthase (ALS) (5) Acetyl-CoA Carboxylase (1) Acetyl-CoA synthetase (1) Ack1 (2) ACSL Family (1) Acyltransferase (2) ADC Linker (4) ADC Payload (4) Adenylate Cyclase (3) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Adrenergic Receptor (4) Akt (27) Aldehyde Dehydrogenase (ALDH) (5) Aldose Reductase (6) Amino Acid Decarboxylase (1) Amino acid Transporter (1) Aminoacyl-tRNA Synthetase (1) AMPK (6) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (6) Angiotensin Receptor (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (76) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (152) Arenavirus (1) Aryl Hydrocarbon Receptor (3) ASCT (2) Atg8/LC3 (1) ATM/ATR (9) ATP-binding cassette (ABC) transporters (1) Aurora Kinase (1) Autophagy (39) Bacterial (115) Bcl-2 Family (55) Bcr-Abl (6) BCRP (6) Beta-lactamase (3) Biochemical Assay Reagents (111) Bombesin Receptor (3) Btk (6) c-Fms (3) 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(SCD) (2) Survivin (2) TAM Receptor (6) Target Protein Ligand-Linker Conjugates (1) Tau Protein (6) TET Protein (1) TGF-beta/Smad (1) TGF-β Receptor (7) Tie (2) TNF Receptor (12) TNK1 (1) Topoisomerase (6) Trace Amine-associated Receptor (TAAR) (1) Transglutaminase (2) Transmembrane Glycoprotein (5) TREM receptor (1) Trk Receptor (10) TRP Channel (13) Tryptophan Hydroxylase (1) Tyrosinase (5) Tyrosine Hydroxylase (1) Vasopressin Receptor (1) VEGFR (15) VRK (1) Wnt (4) YAP (6) YTHDF (1) β-catenin (2)
By Research Areas:	Cancer (682) Cardiovascular Disease (77) Endocrinology (26) Infection (191) Inflammation/Immunology (287) Metabolic Disease (192) Neurological Disease (193)
Click Chemistry:	PROTAC Synthesis (2) Azide (4) Alkynes (3)
Oligonucleotides:	Antigens (2) Fillers (1) Chemokine & Receptors (22) Rat Pre-designed siRNA Sets (1) Solubilizing Agents (1) Phospholipids (1) mRNA (172) Antisense Oligonucleotides (1) Cholesterol (2) Cytidine (1) siRNAs (3) Interferon & Receptors (9) CAR-T (1) MicroRNAs (1) Nucleoside Analogs (1) Mouse Pre-designed siRNA Sets (1) Transcription Factors (17) Human Pre-designed siRNA Sets (1) Interleukin & Receptors (18)

1538

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

126

Peptides

MCE Kits

Inhibitory Antibodies

232

Natural
Products

402

Recombinant Proteins

Isotope-Labeled Compounds

352

Antibodies

Click Chemistry

184

Oligonucleotides

GMP Molecules

Targets Recommended: MicroRNA

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-148104

ACSS2-IN-2 1 Publications Verification	Acetyl-CoA synthetase	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
ACSS2-IN-2 is an *acyl-CoA synthetase short-chain family* member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC₅₀** value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer .

HY-P9966

Enoblituzumab 1 Publications Verification MGA271	CD276/B7-H3	Cancer
Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human B7-H3 protein, a member of the B7 family of immune regulators .

HY-112473

Grassofermata 10+ Cited Publications NAV-2729	Ras	Cancer
Grassofermata is a dual Arf1/Arf6 activation inhibitor. ADP ribosylation factors (Arfs) are members of the Arf family of GTP-binding proteins of the Ras superfamily.

HY-W017982

*CMIT/MIT* (14.5% in water)** CMI/MI	Environmental Pollutants Bacterial Reactive Oxygen Species (ROS) p38 MAPK Mitochondrial Metabolism	Infection Neurological Disease Inflammation/Immunology
CMIT/MIT is a CMIT and MIT mixture. CMIT and MIT are powerful synthetic biocidal substances. CMIT and MIT are used as preservatives in various cosmetics and industrial products. CMIT and MIT are present in many water-soluble consumer products, such as shampoos, toothpastes. CMIT/MIT (3:1 mixture of CMIT and MIT) produces mitochondrial ROS via inhibiting mitochondrial complex I and II. CMIT/MIT (in 3:1 ratio) induces neurotoxicity through the upregulation of the MAPKs signaling pathways. CMIT/MIT can be used in the research of respiratory diseases and neuroblastoma .

HY-165559

Trpvicin	TRP Channel	Inflammation/Immunology
Trpvicin is a potent and subtype-selective TRPV3 inhibitor with IC₅₀s of 0.41 and 0.22 μM for hTRPV3-WT and hTRPV3-G573S mutant, respectively. Trpvicin exhibits minimal effects on other TRP family members (such as TRPV1/2/4/5/6, TRPA1 and TRPM8). Trpvicin inhibits the TRPV3 channel by stabilizing it in a closed state via VSLD-PD binding. Trpvicin accesses additional binding sites inside the central cavity of the G573S mutant to remodel symmetry and block the channel. Trpvicin inhibits itch and hair loss in mouse models. Trpvicin can be used for study of inflammation and immunology .

HY-15191

Sabutoclax 1 Publications Verification BI-97C1	Bcl-2 Family	Cancer
Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC₅₀s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively. Sabutoclax increases Bax, Bim, PUMA and survivin expression .

HY-134086

NSD-IN-2 2 Publications Verification	Histone Methyltransferase	Cancer
NSD-IN-2 is a potent and irreversible NSD inhibitor with inhibitory activity towards members of the NSD family (NSD1/2/3). NSD-IN-2 can be used in research of acute myeloid leukemia .

HY-135299

CH6953755 5 Publications Verification	Src	Cancer
CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC₅₀ of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo .

HY-P0241

Neuromedin B 1 Publications Verification	Endogenous Metabolite	Neurological Disease
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

HY-N2253

Neoruscogenin 1 Publications Verification	ROR	Infection Neurological Disease
Neoruscogenin, a member of the steroidal sapogenin family, is a high-affinity agonist of the nuclear receptor RORα (NR1F1) (EC₅₀ = 0.11 µM) .

HY-112331

SJ000291942 3 Publications Verification	TGF-β Receptor	Cancer
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules.

HY-15948

Kif15-IN-1 4 Publications Verification	Kinesin	Cardiovascular Disease Inflammation/Immunology Cancer
Kif15-IN-1 is an inhibitor of the mitotic *Kinesin family* member 15 (Kif15)**, and is used for the research of cellular proliferative diseases.

HY-125859B

Lactoperoxidase, bovine milk	Bacterial	Infection
Lactoperoxidase, bovine milk is an antimicrobial protein that belongs to the mammalian heme peroxidase family. Lactoperoxidase, bovine milk uses H₂O₂ to catalyze the oxidation of its preferred halide substrates including I ⁻, Br ⁻, F ⁻, or the pseudohalide SCN ⁻ .

HY-101413

Iberin 2 Publications Verification NSC 321801	Apoptosis Endogenous Metabolite Bacterial	Cancer
Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC₅₀ of 2.3 μM in HL60 cell. Iberin induces apoptosis.

HY-15441

Edelinontrine 4 Publications Verification PF-04447943	Phosphodiesterase (PDE)	Neurological Disease
Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant PDE9A (IC₅₀=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC₅₀>1000 nM).

HY-D1379

Azophloxine Acid red 1	Environmental Pollutants Fluorescent Dye	Others
Azophloxine, also known as acid red 1 (AR1), is a member of synthetic red azo dye family .

HY-114165

DJ-V-159 1 Publications Verification	Androgen Receptor	Metabolic Disease
DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).

HY-142686A

SGK1-IN-3 hydrochloride	SGK CDK P-glycoprotein	Inflammation/Immunology
SGK1-IN-3 hydrochloride (Compound 3a) is an ATP-competitive SGK1 inhibitor with an IC₅₀ of <1 nM against hSGK1. SGK1-IN-3 hydrochloride blocks the activity of CDK family members. SGK1-IN-3 hydrochloride serves as a P-glycoprotein substrate. SGK1-IN-3 can be used for the research of osteoarthritis .

HY-109146

Imifoplatin PT-112	Apoptosis DNA Alkylator/Crosslinker	Cancer
Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity .

HY-P3279

EPQpYEEIPIYL 1 Publications Verification	Src	Cancer
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains .

HY-P1985

Notch 1	Notch	Cardiovascular Disease Cancer
Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-N4081

Dracorhodin 1 Publications Verification	Others	Cardiovascular Disease
Dracorhodin, the main component in sanguis draconis, is a flavylium compound belonging to the anthocyanin family. Dracorhodin can induce vasodilatation .

HY-139309

PROTAC Bcl-xL degrader-2	Bcl-2 Family PROTACs	Cancer
PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC₅₀ of 0.6 nM.

HY-150036

Anthramycin	Antibiotic Cholecystokinin Receptor	Cancer
Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice .

HY-144881

(S)-HH2853	Histone Methyltransferase	Inflammation/Immunology Cancer
(S)-HH2853 (compound 200), a PYRIDINO five membered aromatic ring compound, is a potent EZH1/2 dual inhibitor with an IC₅₀ of <100 nM for EZH2_Y641F. (S)-HH2853 has the potential to be used in the research of anti-tumor or autoimmune diseases .

HY-B0866

Ametryn	Environmental Pollutants Herbicide	Metabolic Disease
Ametryn, a member of the Triazine chemical family, is a herbicide which inhibits photosynthesis and other enzymatic processes. Ametryn is effective against annual broadleaf weeds and grasses .

HY-156350

SGC-STK17B-1	DAPK	Cancer
SGC-STK17B-1, a chemical probe, is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC₅₀: 34 nM, K_D: 5.6 nM) .

HY-142686

SGK1-IN-3	SGK P-glycoprotein CDK	Inflammation/Immunology
SGK1-IN-3 (Compound 3a) is an ATP-competitive SGK1 inhibitor with an IC₅₀ of <1 nM against hSGK1. SGK1-IN-3 blocks the activity of CDK family members. SGK1-IN-3 is a P-glycoprotein substrate. SGK1-IN-3 can be used for research on osteoarthritis .

HY-E70122

Uridylate kinase	Others	Others
Uridylate kinase is a member of the nucleoside mono-phosphate (NMP) kinase family and catalyzes the reaction ATP+NMP ADP+NDP with moderate specificity for UMP .

HY-P0274

PGLa	Bacterial Antibiotic	Infection
PGLa, a 21-residue peptide, is an antimicrobial peptide. PGLa is a member of the magainin family of antibiotic peptides found in frog skin and its secretions .

HY-129359

PDP-Pfp	ADC Linker	Cancer
PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .

HY-P1687

Siomycin A	Bacterial Apoptosis	Cancer
Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis .

HY-P1985A

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-W243002

Acetyl-L-homoserine lactone	Bacterial	Infection
Acetyl-L-homoserine lactone is a member of the family of N-acylated homoserine lactones (HSLs). Acetyl-L-homoserine lactone is a polar mediator of cell-cell interactions in bacterial biofilms .

HY-E70888

Lipase, Candida antarctica, expressed in Aspergillus niger	Lipase	Others
Lipase, Candida antarctica, expressed in Aspergillus niger, is a serine hydrolase, which belongs to the α/β hydrolase fold family .

HY-141646

MIT-PZR	Fluorescent Dye	Others
MIT-PZR is a mitochondria-targeted,? low cytotoxicity fluorescent probe that can be used in live cells and in vivo imaging. Ex / Em = 485 / 705 nm

HY-P10680

TFE-IDAtp1-LinA	Liposome	Others
TFE-IDAtp1-LinA is a highly potent amphiphilic carrier, containing a trifluoroethyl-iminodiacetic acid analog of Stp. TFE-IDAtp1-LinA, formed nanoparticles with Cas9 RNP/ssDNA, achieved enhanced green fluorescent protein knockouts with an ED₅₀ of 0.38 nM Cas9/sgRNA ribonucleoproteins (RNP) .

HY-W017982A

*CMIT/MIT* (2.0-2.5% in water)** CMI/MI (2.0-2.5% in water)	Biochemical Assay Reagents	Inflammation/Immunology
CMIT/MIT (CMI/MI) 2.0-2.5% in water is a highly effective preservative, wiht also a skin sensitizing effect. Some regions stipulate that the concentration of CMIT/MIT used must not exceed 0.0015%, and it is prohibited from being used in other cosmetics .

HY-164652

m-BBIG dihydrochloride	Biochemical Assay Reagents	Others
m-BBIG dihydrochloride is a member of Bis-iminoguanidine (BIG) family and can be utilized in synthetic chemistry .

HY-E70409

Diacetinase, bacillus subtilis	Endogenous Metabolite	Metabolic Disease
Diacetinase, Bacillus subtilis is a member of the esterase family and is responsible for catalyzing the hydrolysis of diacetin. This enzyme is used in the measurement of lipase activity .

HY-172432

Plodicitinib	Tyrosinase	Inflammation/Immunology
Plodicitinib is a Janus tyrosine kinase 3/*TEC family* kinase** inhibitor with anti-inflammatory activity .

HY-170667

Autophagy activator-1	Autophagy HSP	Cancer
Autophagy activator-1 (Compound B2) is an autophagy activator Autophagy. Activator-1 ultimately leads to the activation of autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response .

HY-147314

HIV-IN-6	HIV Src	Infection
HIV-IN-6 is a HIV-Ⅰ viral replication inhibitor by targeting Src family kinases (SFK) that interact with Nef protein of the virus, such as Hck .

HY-174536

*Human TFE3 mRNA*	mRNA	Cancer
Human TFE3 mRNA encodes the human transcription factor binding to IGHM enhancer 3 (TFE3) protein, a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences. TFE3 may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins.

HY-RS14419

TFE3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TFE3 Human Pre-designed siRNA Set A contains three designed siRNAs for TFE3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TFE3 Human Pre-designed siRNA Set A TFE3 Human Pre-designed siRNA Set A

HY-150648

S07-2008	Aldose Reductase	Cancer
S07-2008 is a selective aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC₅₀ of 0.16 μM. S07-2008 shows anticancer activities .

HY-129727

(E)-MS0019266	DNA/RNA Synthesis Reactive Oxygen Species (ROS) Mitosis	Others
(E)-MS0019266 is a potent inhibitor of DNA damage repair. (E)-MS0019266 inhibits ribonucleotide reductase by generating reactive oxygen species. (E)-MS0019266 also reduces expression of genes related to cell cycle arrest and mitosis, including polo-like kinase 1, kinesin family member 20a, cyclin B1 and aurora kinase A. (E)-MS0019266 is promising for research of inhibitors of ribonucleotide reductase and polo-like kinase 1 .

HY-129814

MM 42842 free acid	Antibiotic Bacterial	Infection
MM 42842 free acid is a member of the monobactam family of β-lactam antibiotics .

HY-D0910

5-Bromo-6-chloro-1H-indol-3-yl acetate	Biochemical Assay Reagents	Others
5-Bromo-6-chloro-1H-indol-3-yl acetate, a member of the indole family, is a derivative of the aromatic heterocyclic compound indole. It has been used in a variety of research settings, including studies of enzyme kinetics and protein-ligand interactions. 5-Bromo-6-chloro-1H-indol-3-yl acetate is a biomaterial or organic compound that can be used as a biomaterial or organic compound related to life science research .

HY-169500

Mitomycin Z 9a-O-DemethylMiTomycin G	Drug Derivative	Cancer
Mitomycin Z (9a-O-Demethylmitomycin G) is a member of the mitomycin family with an antitumor activity .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N0750

Monocrotaline Maximum Cited Publications 44 Publications Verification Crotaline	Structural Classification Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Crotalaria pallida Ait. Plants Disease Research Fields Cancer	Others
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC₅₀s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. ^[2][6][8].

HY-N6684

Deoxynivalenol 15+ Cited Publications VoMiToxin	Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Metabolic Disease Disease Research Fields Source Classification	P-glycoprotein
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N2342

Procyanidin C1 5+ Cited Publications PCC1	Classification of Application Fields Rosaceae Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Source Classification Cancer	Apoptosis
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

HY-N6718

Filipin III 20+ Cited Publications	Microorganisms Antifungal Classification of Application Fields Antibiotics Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics Source Classification	Antibiotic Fungal
Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure .

HY-N6810

Thymol 4 Publications Verification	Infection Structural Classification Monophenols Classification of Application Fields Labiatae Phenols Derris elliptica (Roxb.) Benth. Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis Bacterial Fungal
Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects .

HY-100593

Spiramycin 1 Publications Verification Rovamycin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Anti-parasitic Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Parasite Antibiotic
Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .

HY-N9497

Galactinol	Source Classification	Galectin Fungal
Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .

HY-N15721

Tryptophan-cholic acid Trp-CA	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	Orphan GPCR GLP Receptor
Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-conjugated bile acid that acts as an endogenous ligand and agonist (EC₅₀=9.6 μM) for the orphan G protein-coupled receptor (GPCR) MRGPRE (Mas-related G protein-coupled receptor family member E). Tryptophan-cholic acid is orally effective but has poor oral absorption and does not cross the blood-brain barrier. Tryptophan-cholic acid promotes the secretion of glucagon-like peptide GLP-1, thereby improving glucose tolerance in diabetic mice. Tryptophan-cholic acid improves glucose tolerance, promotes insulin secretion, and alleviates high-fat diet-induced hepatic steatosis without causing pruritus side effects. Tryptophan-cholic acid is primarily used in research on type 2 diabetes (T2D) .

HY-P0241

Neuromedin B 1 Publications Verification	Natural Products Animals Endogenous metabolite Source Classification	Endogenous Metabolite
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

HY-N2253

Neoruscogenin 1 Publications Verification	Liliaceae Plants Ruscus aculeata Linn. Steroids Source Classification	ROR
Neoruscogenin, a member of the steroidal sapogenin family, is a high-affinity agonist of the nuclear receptor RORα (NR1F1) (EC₅₀ = 0.11 µM) .

HY-101413

Iberin 2 Publications Verification NSC 321801	Natural Products other families Classification of Application Fields Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite Bacterial
Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC₅₀ of 2.3 μM in HL60 cell. Iberin induces apoptosis.

HY-N2147

Phorbol 4β-Phorbol	Classification of Application Fields Terpenoids Croton tiglium Linn. Diterpenoids Euphorbiaceae Plants Disease Research Fields Source Classification Cancer	Others
Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo .

HY-N2374

Eupatorin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Apoptosis NF-κB MMP Adrenergic Receptor
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, IL-1β and TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle arrest, and reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by CYP1A1 and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia .

HY-N2084

Perillartine 2 Publications Verification DL-Perillartine	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Sweeteners Source Classification Food Research	Endogenous Metabolite
Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.

HY-W035362

ω-Pentadecalactone	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Environmental Pollutants
ω-Pentadecalactone, a macrocyclic lactone, is a fragrance ingredient. ω-Pentadecalactone is a member of the fragrance structural group macrocyclic lactone and lactide derivative .

HY-W007426

N-Methylbenzylamine	Alkaloids Classification of Application Fields Other Alkaloids Ephedraceae Other Diseases Plants Disease Research Fields Ephedra sinica Stapf Source Classification	Drug Derivative
N-methylbenzylamine is a member of phenylmethylamines. N-methylbenzylamine can be found in carrot, which makes N-methylbenzylamine a potential biomarker for the consumption of these food products .

HY-W011690

L-Homocystine	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

HY-W016278

Gamma-undecalactone	Source Classification	Environmental Pollutants Biochemical Assay Reagents
Gamma-undecalactone consists of a five-membered dihydrofuran ring with an ester group and a heptyl chain. This compound has a fruity smell and is commonly used as a flavor additive in various food and beverage products such as coffee, tea and baked goods.

HY-N6889

Rebaudioside I	Structural Classification other families Classification of Application Fields Terpenoids Other Diseases Diterpenoids Plants Disease Research Fields Sweeteners Source Classification Food Research	Drug Derivative
Rebaudioside I is a natural non-caloric high-potency sweetener belonging to the steviol glycoside family, which can be isolated from Stevia rebaudiana Morita .

HY-W008097

3,3-Dimethylglutaric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
3,3-Dimethylglutaric acid, a member of methyl-branched fatty acids, is a endogenous metabolite occasionally found in human urine. 3,3-Dimethylglutaric acid can be used as a ligand to synthesize metal complexes .

HY-N4081

Dracorhodin 1 Publications Verification	Cardiovascular Disease Anthocyans Flavonoids other families Classification of Application Fields Plants Disease Research Fields Source Classification	Others
Dracorhodin, the main component in sanguis draconis, is a flavylium compound belonging to the anthocyanin family. Dracorhodin can induce vasodilatation .

HY-108486

Herbimycin A	Infection Quinones Microorganisms Classification of Application Fields Benzene Quinones Disease Research Fields Source Classification	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a *Src family* kinase** inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-N6810R

Thymol (Standard)	Structural Classification Microorganisms Myroxylon balsamum (L.) Harms Labiatae Phenols Plants Source Classification	Reference Standards Bacterial Fungal Apoptosis
Thymol (Standard) is the analytical standard of Thymol. This product is intended for research and analytical applications. Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects .

HY-N4097

Incensole	other families Terpenoids Diterpenoids Plants Source Classification	Others
Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression .

HY-W102375

4-Acetoxycinnamic acid	Kaempferia galanga L. Classification of Application Fields Simple Phenylpropanols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification Zingiberaceae	Drug Intermediate
4-Acetoxycinnamic acid is an acetate ester obtained by the formal condensation of the hydroxy group of trans-4-coumaric acid with acetic acid. 4-Acetoxycinnamic acid is a member of cinnamic acids and a member of phenyl acetates. 4-Acetoxycinnamic acid derives from a trans-4-coumaric acid .

HY-76504

2,6-Dimethoxybenzoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2,6-Dimethoxybenzoic acid is a member of organic compounds known as o-methoxybenzoic acids and derivatives.

HY-76224

3-Furaldehyde	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
3-Furaldehyde is a member of furans and an aldehyde, and can be used to synthesize the neoclerodane diterpene Salvinorin A .

HY-N4218

Saikosaponin B4	Triterpenes Classification of Application Fields Terpenoids Metabolic Disease Plants Umbelliferae Disease Research Fields Source Classification Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Saikosaponin B4 is a member of saikosaponins isolated from the roots of Bupleurum chinensis, selectively inhibits ACTH-induced lipolysis .

HY-124073

Dihydrocapsiate	Monophenols Capsicum annuum L. Classification of Application Fields Phenols Metabolic Disease Plants Solanaceae Disease Research Fields Source Classification	TRP Channel
Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease .

HY-133683

N-(3-Oxotetradecanoyl)-DL-homoserine lactone 3-Oxo-C14-AHL	Natural Products Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Bacterial
N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule .

HY-N5075

Quercetin 3-O-glucoside-7-O-rhamnoside	Structural Classification Flavonols Flavonoids Phenols Polyphenols Arabidopsis thaliana Plants Brassicaceae Source Classification	Others
Quercetin 3-O-glucoside-7-O-rhamnoside is a member of flavonoid glycosides group with an inhibitory activity on the CNS .

HY-117586

9-PAHPA	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
9-PAHPA is a fatty acid esters of hydroxy fatty acid (FAHFA). FAHFAs are a new family of endogenous lipids, have antidiabetic and anti-inflammatory effects .

HY-N7112A

Leucomycin tartrate Kitasamycin tartrate	Natural Products Animals Source Classification	Antibiotic Bacterial
Leucomycin tartrate (Kitasamycin tartrate) is a potent 16-membered macrolideantibiotic .

HY-N2342R

Procyanidin C1 (Standard) PCC1 (Standard)	Structural Classification Flavonoids Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Biflavones Source Classification	Reference Standards Apoptosis
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

HY-W415953

Periplanetin	Animals Saccharides Monosaccharides Source Classification	Sex Pheromone
Periplanetin is a peptide of the insect lipomotor hormone family (AKH family) that can be isolated from the secretion of the cervical organ of Periplaneta americana L. and Blatta orientalis L. The periplanetin peptide has potential analgesic activity and lowers the threshold of tonic seizures .

HY-W414069

Thiocholesterol	Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Liposome
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery .

HY-156047

Oasomycin B	Natural Products Microorganisms Source Classification	Endogenous Metabolite
Oasomycin B, a member of the desertomycin family, is a polyketide. Oasomycin B can be isolated from Streptomyces sp. Oasomycin B, lacking the positively charged amino moiety, has no significant antibacterial activity and fails to induce Orsellinic acid (HY-N3126) production in A. nidulans .

HY-155852

Lepadin H	Structural Classification Alkaloids Animals Marine natural products Other marine organisms Quinoline Alkaloids Source Classification	Ferroptosis Apoptosis ACSL Family Glutathione Peroxidase Reactive Oxygen Species (ROS)
Lepadin H is a ferroptosis inducer and apoptosis inducer with in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. Lepadin H reduces GPX4 and SLC7A11 levels, increases p53 and ACSL4 expression, drives lipid hydroperoxide production, elevates reactive oxygen species (ROS) levels, reduces cellular glutathione (GSH) levels, induces lipid peroxidation and G₂/M phase cell cycle arrest, and suppresses clonogenic growth and migration of cancer cells.Lepadin H can be used for the research of melanoma .

HY-N6684R

Deoxynivalenol (Standard) VoMiToxin (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source Classification	P-glycoprotein Reference Standards
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N10623

5-epi-Arvestonate A	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Seriphidium transiliense Disease Research Fields Cancer	Tyrosinase
5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells .

HY-N11048

Amycolatopsin A	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Disease Research Fields Cancer Source Classification	Bacterial
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

HY-W035362R

ω-Pentadecalactone (Standard)	Structural Classification Natural Products other families Plants Source Classification	Biochemical Assay Reagents Reference Standards
ω-Pentadecalactone, a macrocyclic lactone, is a fragrance ingredient. ω-Pentadecalactone is a member of the fragrance structural group macrocyclic lactone and lactide derivative .

HY-113801

N-(3-Oxooctanoyl)-DL-homoserine lactone (Rac)-3-oxo-C8-HSL	Natural Products Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite
N-(3-Oxooctanoyl)-DL-homoserine lacton is a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, with stereochemistry-dependent growth regulatory activity for roots .

HY-169500

Mitomycin Z 9a-O-DemethylMiTomycin G	Quinones Structural Classification Microorganisms Benzene Quinones Source Classification	Drug Derivative
Mitomycin Z (9a-O-Demethylmitomycin G) is a member of the mitomycin family with an antitumor activity .

HY-N10021

Benzo[e]pyrene	Natural Products Minerals Source Classification	Others
Benzo[e]pyrene occurs in fossil fuels and is a highly toxic member of a family of compounds called polyaromatic hydrocarbons (PAHs) .

HY-113627

Undecylprodigiosin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial Apoptosis
Undecylprodigiosin, a member of the family of prodiginines, is a potent antibiotic. Undecylprodigiosin can selectively induce apoptosis in human breast carcinoma cells independent of p53. Undecylprodigiosin shows immunosuppressive, anticancer properties and antimicrobial activities .

HY-N2253R

Neoruscogenin (Standard)	Structural Classification Liliaceae Plants Ruscus aculeata Linn. Steroids Source Classification	Reference Standards ROR
Neoruscogenin (Standard) is the analytical standard of Neoruscogenin. This product is intended for research and analytical applications. Neoruscogenin, a member of the steroidal sapogenin family, is a high-affinity agonist of the nuclear receptor RORα (NR1F1) (EC₅₀ = 0.11 μM) .

HY-126695

Altromycin B	Quinones Microorganisms Anthraquinones Source Classification	Antibiotic
Altromycin B is a member of the pluramycin antibiotic family isolated from South African bush soil. Altromycin B shows selective antibacterial activity against Gram-positive bacteria and has in vivo activity against P388 leukemia, colon cancer, lung cancer, and ovarian cancer.

HY-N14729

De-N-methylpamamycin-593A	Natural Products Microorganisms Source Classification	Fungal
De-N-methylpamamycin-593A is a 16-membered ring macrocyclic dilactone. De-N-methylpamamycin-593A has Aerial Mycelium-inducing activity .

HY-N14730

De-N-methylpamamycin-593B	Natural Products Microorganisms Source Classification	Fungal
De-N-methylpamamycin-593B is a 16-membered ring macrocyclic dilactone. De-N-methylpamamycin-593B has Aerial Mycelium-inducing activity .

Cat. No.	상품명	Chemical Structure

HY-131968

BMS-986202

1 Publications Verification

BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC₅₀ value of 0.19 nM and a K_i of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC₅₀ value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium .

HY-10181S

Dasatinib-d8 1 Publications Verification
Dasatinib-d₈ (BMS-354825-d₈) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium
α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-W011338S

Benzyl butyl phthalate-d4

Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate . Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-113038AS1

α-Hydroxyglutaric acid-d4 disodium

α-Hydroxyglutaric acid-d₄ (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-15917S2

DL-Dithiothreitol-d6
DL-Dithiothreitol-d₆ is the deuterated form of DL-Dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond .

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) .

HY-N0573S

Umbelliferone-d5

Umbelliferone-d₅ (7-Hydroxycoumarin-d₅) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-W011690S

L-Homocystine-d8
L-Homocystine-d₈ is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

HY-Y1275S

N-Methylpyrrolidone-d9

N-Methylpyrrolidone-d₉ (NMP-d₉) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD₅₀ value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-10087S

Navitoclax-d8 1 Publications Verification
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-B1876S

Nicosulfuron-d6
Nicosulfuron-d₆ is the deuterium labeled Nicosulfuron . Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity .

HY-10394S1

Linezolid-d8
PNU-100766-d₈ is deuterated labeled Linezolid (HY-10394). Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .

HY-133685S

N-Hexanoyl-L-Homoserine lactone-d3
N-Hexanoyl-L-Homoserine lactone-d₃ (C6-HSL-d₃) is deuterium labeled N-Hexanoyl-L-homoserine lactone. N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats .

HY-133167S

Clothianidin-d3

Clothianidin-d₃ is the deuterium labeled Clothianidin.Clothianidin-d₃ is a neonicotinoid insecticide. Clothianidin-d₃ shows excellent long-term control effect in small doses against various insect pests such as Coleoptera, Thysanoptera, Lepidoptera, Diptera, Homoptera, Heteroptera, Orthoptera and Isoptera families. Clothianidin-d₃ has various application methods and high safety for crops .

HY-B0965AS

Thioridazine-d3 hydrochloride

Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) .

HY-P1624S1

Teduglutide-Leu(13C6,15N) sodium

Teduglutide-Leu( ¹³C₆, ¹⁵N) (ALX-0600-Leu( ¹³C₆, ¹⁵N)) sodium is the ¹³C- and ¹⁵N-labeled Teduglutide (HY-P1624). Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis .

HY-141582S

Ceramide 3-d3

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. Ceramide 3 is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.

HY-N1480S1

(-)-Fucose-13C-1
(-)-Fucose- ¹³C-1 is the ¹³C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[

HY-10261S

Afatinib-d6
Afatinib-d₆ (BIBW 2992-d₆) is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor .

HY-15917S

DL-Dithiothreitol-d10
DL-Dithiothreitol-d₁₀ is the deuterated form of DL-Dithiothreitol. DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

HY-Y1275S1

N-Methylpyrrolidone-d3
N-Methylpyrrolidone-d₃ is the deuterium labeled N-Methylpyrrolidone . N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-13311S

Infigratinib-d3
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC₅₀ values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively .

HY-B0211S1

Riluzole-13C6
Riluzole- ¹³C₆ (PK 26124- ¹³C₆) is ¹³C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-B1859S1

Isoproturon-d3
Isoproturon-d₃ is the deuterium labeled Isoproturon . Isoproturon belongs to the phenylurea herbicide family and is a systemic and selective herbicide. Isoproturon is widely applied for killing weeds in farmland, which can be used in the control of annual grasses and broad-leaved weeds in spring and winter wheat, winter rye and spring and winter barley .

HY-W779244

1H-Pyrazole-3,4,5-d3
1H-Pyrazole-3,4,5-d₃ is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-N6715S

Tenuazonic acid-13C10

Tenuazonic acid- ¹³C₁₀ is ¹³C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-B0866S

Ametryn-13C,d3
Ametryn- ¹³C,d₃ is the ¹³C- and deuterium labeled Ametryn. Ametryn, a member of the Triazine chemical family, is a herbicide which inhibits photosynthesis and other enzymatic processes. Ametryn is effective against annual broadleaf weeds and grasses .

HY-12383S

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

HY-B0223S

Albendazole-d3
Albendazole-d₃ is the deuterium labeled Albendazole, which is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .

HY-N6810S

Thymol-d13
Thymol-d₁₃ is the deuterium labeled Thymol . Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects .

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-N1480S

(-)-Fucose-13C
(-)-Fucose- ¹³C is the ¹³C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti

HY-W007426S

N-Methylbenzylamine-d3
N-Methylbenzylamine-d₃ is the deuterium labeled N-Methylbenzylamine . N-methylbenzylamine is a member of phenylmethylamines. N-methylbenzylamine can be found in carrot, which makes N-methylbenzylamine a potential biomarker for the consumption of these food products .

HY-N1480S2

(-)-Fucose-13C-2
(-)-Fucose- ¹³C-2 is the ¹³C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[

HY-N1480S3

(-)-Fucose-13C-3
(-)-Fucose- ¹³C-3 is the ¹³C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[

HY-15917S1

DL-Dithiothreitol-d10-1
DL-Dithiothreitol-d₁₀-1 is the deuterated form of DL-dithiothreitol. DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-Dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond .

HY-B1176S

Equilin-d4
Equilin-d₄ is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .

HY-B0106AS

Etiracetam-d3
Etiracetam-d₃ is the deuterium labeled Etiracetam. Etiracetam (UCB 6474) is an acetylcholine agonist and a nootropic drug of the racetam family. Less active than its S-enantiomer Levetiracetam (UCB L059) .

HY-B1176S1

Equilin-d2
Equilin-d₂ (7-Dehydroestrone-d₂) is deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .

HY-135397S

(R)-Linezolid-d3
(R)-Linezolid-d₃ ((R)-PNU-100766-d₃) is the deuterium labeled (R)-Linezolid. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis .

HY-77813S

Benzyl isothiocyanate-d7
Benzyl isothiocyanate-d₇ is the deuterium labeled Benzyl isothiocyanate. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity . Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells .

HY-13272S3

Dacomitinib-d10
Dacomitinib-d₁₀ is deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC₅₀s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .

HY-13272S2

Dacomitinib-d10 dihydrochloride
Dacomitinib-d₁₀ dihydrochloride is the deuterium labeled Dacomitinib dihydrochloride. Dacomitinib (PF-00299804) dihydrochloride is a specific and irreversible inhibitor of the ERBB family of kinases with IC₅₀s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .

HY-126047AS

(R,S)-Anatabine-d4
(R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine (HY-126047A). (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use .

HY-B0211S

Riluzole-13C,15N2
Riluzole- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Riluzole . Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM .

HY-B1459AS

Dicloxacillin-13C4
Dicloxacillin- ¹³C₄ is the ¹³C labeled Dicloxacillin (HY-B1459A) . Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus .

HY-10261S1

Afatinib-d4
Afatinib-d₄ is the deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

HY-10261AS

Afatinib-d6 dimaleate
Afatinib-d₆ (dimaleate) is the deuterium labeled Afatinib dimaleate. Afatinib dimaleate is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively .

Targets Recommended: MicroRNA

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-50751G

Linifanib ABT-869; AL-39324	VEGFR PDGFR	Cancer
Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC₅₀s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells .

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