244 Results for "

active component

" in MedChemExpress (MCE) Product Catalog:
Products (244)

244 Results for "active component" in MCE Product Catalog:

87
Capsaicin
Capsaicin
0 Images
87 Publications Verification
Cat. No.: HY-10448
CAS No.: 404-86-4
Purity:  99.79%
Synonyms: (E)-Capsaicin
Category:  

Capsicum annuum L. Monophenols Phenols Plants Solanaceae Disease Research Fields Biological Pesticide Research Cancer Agricultural Research

Target:  

Environmental Pollutants TRP Channel Autophagy Endogenous Metabolite Apoptosis

Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .
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43
Astragaloside IV
Astragaloside IV
0 Images
43 Cited Publications
Cat. No.: HY-N0431
CAS No.: 84687-43-4
Category:  

Triterpenes Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Cancer

Target:  

MMP ERK JNK

Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
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30
Infliximab
Infliximab
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30 Cited Publications
Cat. No.: HY-P9970
CAS No.: 170277-31-3
Synonyms: Avakine; CT-P13; SB2; TA-650

Target:  

TNF Receptor

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .
The component ratio of this product is Active ingredient : Excipients = 9 : 47.
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17
Ginsenoside Rg1
Ginsenoside Rg1
0 Images
17 Cited Publications
Cat. No.: HY-N0045
CAS No.: 22427-39-0
Synonyms: Panaxoside A; Panaxoside Rg1
Category:  

Panax ginseng C. A. Meyer Triterpenes Neurological Disease Anti-aging Terpenoids Plants Disease Research Fields Araliaceae Cancer

Target:  

Amyloid-β NF-κB Apoptosis

Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.
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12
Bufalin
Bufalin
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12 Cited Publications
Cat. No.: HY-N0877
CAS No.: 465-21-4
Category:  

Animals Disease Research Fields Cancer Steroids

Target:  

Na+/K+ ATPase

Bufalin is an active component isolated from Chan Su, acts as a potent Na +/K +-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .
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7
Lysophosphatidylcholines
Lysophosphatidylcholines
0 Images
7 Cited Publications
Cat. No.: HY-139414
CAS No.: 9008-30-4
Purity:  ≥99.0%
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis .
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6
Safranal
Safranal
0 Images
6 Cited Publications
Cat. No.: HY-N7560
CAS No.: 116-26-7
Category:  

Ketones, Aldehydes, Acids Lridaceae Plants Crocus sativus L.

Target:  

Keap1-Nrf2

Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research .
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6
Belimumab
Belimumab
0 Images
6 Cited Publications
Cat. No.: HY-P9952
CAS No.: 356547-88-1
Synonyms: LymphoStat B

Target:  

TNF Receptor CD20

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research . The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.
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5
Epimedin B
Epimedin B
0 Images
5 Cited Publications
Cat. No.: HY-N0259
CAS No.: 110623-73-9
Synonyms: Epmedin B
Category:  

Flavonols Flavonoids Monophenols Other Diseases Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields

Target:  

JNK Estrogen Receptor/ERR p38 MAPK PI3K Akt AMPK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Bcl-2 Family

Epimedin B (Epmedin B) is a flavonoid active component found in Epimedium, with oral activity, and exhibits anti-osteoporotic and neuroprotective effects. Epimedin B inhibits RANKL-induced osteoclast differentiation, F-actin ring formation, and mature osteoclast bone resorption, inhibits the phosphorylation of JNK, p38 MAPK, PI3K, and AKT, activates the AMPK-Nrf2 antioxidant pathway, and reduces cellular and mitochondrial ROS. Epimedin B acts on ESR1 and exerts its effects via GPER. Epimedin B alleviates bone loss and improves bone microstructure in vivo, and in Parkinson's models protects dopaminergic neurons and maintains striatal dopamine levels through anti-apoptotic and anti-endoplasmic reticulum stress effects. Epimedin B can be used for research related to osteoporosis, diabetic osteoporosis, and Parkinson's disease .
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4
Epimedin A
Epimedin A
0 Images
4 Cited Publications
Cat. No.: HY-N0257
CAS No.: 110623-72-8
Category:  

Flavonols Flavonoids Monophenols Other Diseases Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields

Target:  

PI3K Akt NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Heme Oxygenase (HO) SOD Caspase Interleukin Related

Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases .
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4
Ginsenoside Rg2
Ginsenoside Rg2
0 Images
4 Cited Publications
Cat. No.: HY-N0602
CAS No.: 52286-74-5
Synonyms: Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2
Category:  

Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Neurological Disease Terpenoids Plants Disease Research Fields Araliaceae Cancer

Target:  

NF-κB Amyloid-β

Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ1-42 accumulation.
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4
Tenuigenin
Tenuigenin
0 Images
4 Cited Publications
Cat. No.: HY-N0802
CAS No.: 2469-34-3
Synonyms: Senegenin
Category:  

Triterpenes Terpenoids Polygalaceae Plants Disease Research Fields Inflammation/Immunology Polygala tenuifolia Willd.

Target:  

NF-κB Bacterial

Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect .
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3
Sacubitril
Sacubitril
0 Images
3 Cited Publications
Cat. No.: HY-15407
CAS No.: 149709-62-6
Purity:  99.92%
Synonyms: AHU-377
Target:  

Neprilysin

Research Areas:  

Infection Cardiovascular Disease

Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 .
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3
Atractylenolide III
Atractylenolide III
0 Images
3 Cited Publications
Cat. No.: HY-N0203
CAS No.: 73030-71-4
Synonyms: ICodonolactone; 8β-Hydroxyasterolide
Category:  

Terpenoids Sesquiterpenes Astragalus caprinus L. Plants Compositae Disease Research Fields Cancer

Target:  

Apoptosis

Atractylenolide III (ICodonolactone) is the main component of Atractylodes rhizome and has the activity of inducing apoptosis in lung cancer cells. Atractylenolide III is an orally active gastroprotective agent .
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3
Sacubitril sodium
Sacubitril sodium
0 Images
3 Cited Publications
Cat. No.: HY-15407B
CAS No.: 149690-05-1
Purity:  99.95%
Synonyms: AHU-377 sodium
Target:  

Neprilysin

Research Areas:  

Infection Cardiovascular Disease

Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .
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3
Capsaicin (Standard)
Capsaicin (Standard)
0 Images
3 Cited Publications
Cat. No.: HY-10448R
CAS No.: 404-86-4
Purity:  99.38%
Synonyms: (E)-Capsaicin (Standard)
Category:  

Capsicum annuum L. Phenols Plants Solanaceae Disease Research Fields Biological Pesticide Research Cancer Agricultural Research

Target:  

Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite

Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .
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3
(±)-Alliin
(±)-Alliin
0 Images
3 Cited Publications
Cat. No.: HY-126085
CAS No.: 17795-26-5
Purity:  98.21%
Synonyms: (±)-L-Alliin
Category:  

Infection Liliaceae Ketones, Aldehydes, Acids Plants Disease Research Fields  A．Sativam L. var．Viviparum Regel

Target:  

SARS-CoV

(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro) .
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3
Asatone
Asatone
0 Images
3 Cited Publications
Cat. No.: HY-N6826
CAS No.: 38451-63-7
Category:  

Asarum sieboldii Miq. Natural Products Plants Disease Research Fields Inflammation/Immunology Aristolochiaceae

Target:  

NF-κB

Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways .
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3
Tussilagone
Tussilagone
0 Images
3 Cited Publications
Cat. No.: HY-N1388
CAS No.: 104012-37-5
Category:  

Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Inflammation/Immunology Tephrosia purpurea (L.) Pers.

Target:  

Others

Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice .
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3
Cotinine
Cotinine
0 Images
3 Cited Publications
Cat. No.: HY-B1178
CAS No.: 486-56-6
Synonyms: (-)-Cotinine; (S)-Cotinine; NIH-10498
Category:  

Alkaloids Pyrrole Alkaloids Nicotiana tabacum L. Other Diseases Pyridine Alkaloids Plants Solanaceae Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite nAChR

Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .
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