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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
208 Results for "
fructose
" in MedChemExpress (MCE) Product Catalog:
Products (208)
208 Results for "fructose" in MCE Product Catalog:
12
7
7 Cited Publications
Cat. No.: HY-16307
CAS No.: 261365-11-1
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MB05032 is a fructose-1,6-bisphosphatase (FBP1/FBPase) inhibitor with an IC50 value of 16 nM. MB05032 blocks FBP1-mediated glycolysis inhibition in NK cells, restores NK cell glucose uptake, lactate production, degranulation, perforin production, and cytotoxicity against gastric cancer cells. MB05032 elevates ATP/ADP ratios, increases glucose utilization, and enhances insulin secretion in pancreatic β-cells. MB05032 increases neutrophil adhesion, phagocytosis, and mRNA abundance of HKII, ITGA9, CD36 in subclinically hypocalcemic dairy cows. MB05032 inhibits gluconeogenesis in hepatocytes, acts as the active metabolite of prodrug Managlinat dialanetil (MB06322) (HY-14955). MB05032 can be used for the research of gastric cancer, type 2 diabetes, subclinical hypocalcemia, and insulin resistance .
4
Category:
Cardiovascular Disease other families Plants Disease Research Fields Saccharides Monosaccharides
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3
3 Cited Publications
Synonyms: 3-Hydroxy-4-methoxycinnamic acid
Category:
Ranunculaceae Metabolic Disease Plants Cimicifuga foetida Linn. Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Endocrinology
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3
3 Cited Publications
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5MPN is a first-in-class, potent, orally active and selective 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) inhibitor. 5MPN appears to be a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN does not inhibit PFK-1 or PFKFB3. 5MPN targets the sugar metabolism of tumors and suppresses proliferation of multiple human cancer cell lines .
2
2
2 Cited Publications
Cat. No.: HY-N0668
CAS No.: 64849-39-4
2
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Hydroxylamine (50% w/w in water) is an inorganic highly reactive compound and antibacterial agent. Hydroxylamine (50% w/w in water) acutely activates the transport activity of GLUT1, inhibits Monoamine oxidase activity. Hydroxylamine (50% w/w in water) inhibits nitrite oxidizing bacteria. Hydroxylamine (50% w/w in water) activates glucose uptake. Hydroxylamine (50% w/w in water) can be used in the research of inflammatory diseases and allergies[1][2][3][4] .
2
2 Cited Publications
Cat. No.: HY-W002105
CAS No.: 3238-40-2
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1
1 Cited Publications
Synonyms: 4-O-β-D-Galactopyranosyl-D-fructose
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1 Cited Publications
Cat. No.: HY-112253A
CAS No.: 71662-09-4
Category:
Human Gut Microbiota Metabolites Natural Products Other Diseases Endogenous metabolite Disease Research Fields
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1
1 Cited Publications
Synonyms: beta-D-Fructopyranose (Standard)
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1
1 Cited Publications
Cat. No.: HY-W179181
CAS No.: 852702-51-3
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MSNBA is a potent and selective GLUT5 fructose transport inhibitor with an IC50 of 0.10 mM. MSNBA does not affect the transport activity of human GLUT1, GLUT2, GLUT3, GLUT4 or bacterial GlcPSe. MSNBA competitively inhibits GLUT5 fructose uptake with a Ki of 3.2 μM in MCF7 cells. MSNBA can be used for the study of cancer or diabetes .
1
1 Cited Publications
Cat. No.: HY-N1499
CAS No.: 13133-07-8
Category:
Polysaccharides Rubiaceae Metabolic Disease Plants Morinda officinalis How Disease Research Fields Saccharides
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1
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Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .
1
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Sucrose phosphorylase is a bacterial transglucosidase that catalyzes the conversion of sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose. The glucosylated Sucrose phosphorylase can also be hydrolyzed into α-D-glucose, or transfer the glucoyl to the hydroxyl group of the receptor, and then decomposed into new α-D-glucoside products. The enzymatic activity of base phosphorylase to substrate and product is weak .
1
1 Cited Publications
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1
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Alrestatin (AY-22284) is an aldose reductase inhibitor. Alrestatin reduces fructose levels in the uterine fluid of mice. Alrestatin interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin can be used in studies related to diabetes and reproductive diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
