CM-579
CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 1846570-40-8
- Formula: C29H40N4O3
- Molecular Weight:492.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
DNA Methyltransferase 32 nM (IC50) |
DNMT1 1.5 nM (Kd) |
DNMT3A 92 nM (IC50) |
DNMT3B 1000 nM (IC50) |
G9a 16 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MM1.S | GI50 |
3842 nM
Compound: 6; CM-579
|
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
|
[PMID: 33661013] |
| OCI-Ly10 | GI50 |
<31 nM
Compound: 12
|
Antiproliferative activity against human OCI-LY10 cells after 48 hrs by MTS assay
Antiproliferative activity against human OCI-LY10 cells after 48 hrs by MTS assay
|
[PMID: 29890830] |
| OCI-Ly3 | GI50 |
202 nM
Compound: 12
|
Antiproliferative activity against human OCI-LY3 cells after 48 hrs by MTS assay
Antiproliferative activity against human OCI-LY3 cells after 48 hrs by MTS assay
|
[PMID: 29890830] |
Chemical Information
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CAS No. 1846570-40-8
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Molecular Weight 492.65
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Formula C29H40N4O3
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SMILES
CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)