TMU454
TMU454 is a prototype GalNAc-PROTAC conjugate. TMU454 binds to ASGPR on the membrane of cells, and then is internalized via ASGPR-mediated endocytosis. TMU454 selectively degrades BRD4. TMU454 exhibits anticancer activity against hepatocellular carcinoma.
For research use only. We do not sell to patients.
- Formula: C142H214ClN27O44S2
- Molecular Weight:3102.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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BRD4 |
Chemical Information
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Molecular Weight 3102.96
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Formula C142H214ClN27O44S2
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SMILES
OC[C@@H](O1)[C@H](O)[C@H](O)[C@@H](NC(C)=O)[C@@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@H]2[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]3[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)=O)=O)NC(CCCC4=CN(N=N4)CCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C5)=CC=C5COC(O[C@@H](C6)C[C@@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)N6C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H](N=C9C(C=C%10)=CC=C%10Cl)C%11=NN=C(C)N%11C%12=C9C(C)=C(C)S%12)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TMU454 Related Classifications
HY-180909 Related Classifications
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