NFATC1 - nuclear factor of activated T cells 1 Gene

Also Known as NFAT2; NFATc; NF-ATC; NF-ATc1.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4772

About NFATC1

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:79,395,930-79,529,323 (from NCBI)

This gene has 18 transcripts (splice variants), 265 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 7.4), spleen (RPKM 6.0) and 24 other tissues.

Summary

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

NFATC1 Products (10)

mRNA	Protein	Name
NM_001278669.2	NP_001265598.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform F
NM_001278670.2	NP_001265599.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform G
NM_001278672.2	NP_001265601.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform H
NM_001278673.2	NP_001265602.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform J
NM_001278675.2	NP_001265604.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform I
NM_006162.5	NP_006153.2	nuclear factor of activated T-cells, cytoplasmic 1 isoform B
NM_172387.3	NP_765975.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform C
NM_172388.3	NP_765976.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform D
NM_172389.3	NP_765977.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform E
NM_172390.3	NP_765978.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nucleic acid binding	EXP EXP: Inferred from Experiment	8990122	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17882263	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	14979875	GOA
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	14749367	GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	23853098	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14749367	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14979875	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14979875	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	14979875	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	15304486	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12370307	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFATC1 Protein Structure

RHD_DNA_bind

TIG

0
200
400
600
800
943 a.a.

Protein Preferred Names	Protein Names
nuclear factor of activated T-cells, cytoplasmic 1	NFAT transcription complex cytosolic component

NFATC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NFATC1	O95644	ATF2	Homo sapiens	P15336	TAP	25609649
Intra	NFATC1	O95644	HOXC13	Homo sapiens	P31276	TAP	25609649
Intra	NFATC1	O95644	OGT	Homo sapiens	O15294	Anti Bait CoIP	17882263
Intra	NFATC1	O95644	CREB1	Homo sapiens	P16220	TAP	25609649
Intra	NFATC1	O95644	ATF3	Homo sapiens	P18847	TAP	25609649
Intra	NFATC1	O95644	ATF1	Homo sapiens	P18846	TAP	25609649
Intra	NFATC1	O95644	JUN	Homo sapiens	P05412	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

NFATC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80243	NFAT2 Antibody (YA270)	WB, IHC-P, FC	Human
HY-P81644	Phospho-NFAT2 (Ser237) Antibody (YA1389)	WB	Human, Mouse
HY-P81644A	Phospho-NFAT2 (Ser237) Antibody (YA1389)(PBS only)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Tricuspid Atresia	Congenital Agenesis Of The Tricuspid Valve
Cherubism	CRBM Familial Benign Giant-Cell Tumor Of The Jaw Familial Fibrous Dysplasia Of Jaw Familial Multilocular Cystic Disease Of The Jaws
Osteonecrosis	Bone Necrosis Avascular Necrosis Of Bone Aseptic Necrosis Necrosis Of Bone Nos Aseptic Osteonecrosis Aseptic Necrosis Of Bone, Site Unspecified Aseptic Or Avascular Bone Necrosis Aseptic Necrosis Of Bone Necrotic Bone Necrotizing Bone Spontaneous Osteonecrosis Osteoradionecrosis
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Osteonecrosis Of The Jaw
Colitis
Osteomyelitis
Bone Epithelioid Hemangioma	Bone Hemangioma Hemangioma Of Bone Osseous Epithelioid Hemangioma Osseous Hemangioma
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Leukostasis
Bone Remodeling Disease
Osteopetrosis, Autosomal Recessive 2	OPTB2 Autosomal Recessive Osteopetrosis 2 Osteopetrosis, Mild Autosomal Recessive Form Osteoclast-Poor Osteopetrosis Osteopetrosis, Osteoclast-Poor Mild Autosomal Recessive Form Osteopetrosis Osteopetrosis Autosomal Recessive 2 Autosomal Recessive Osteopetrosis Type 2 Osteopetrosis Osteoclast-Poor Osteopetrosis, Autosomal Recessive, Type 2
Metatropic Dysplasia	Metatropic Dwarfism MTD Metatropic Dysplasia Type 1 Metatropic Dysplasia, Nonlethal Dominant
Bone Resorption Disease	Bone Resorption
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Chronic Apical Periodontitis	Apical Periodontitis Nos Apex Periodontitis Periapical Infection Nos
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Glucocorticoid-Induced Osteoporosis	Steroid-Induced Osteoporosis
Familial Expansile Osteolysis	FEO Mccabe Disease Osteolysis, Familial Expansile Polyostotic Osteolytic Dysplasia, Hereditary Expansile Hepod Expansile Osteolysis, Familial Eof Hereditary Expansile Polyostotic Osteolytic Dysplasia
Ischemic Bone Disease
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis
Lymphedema-Distichiasis Syndrome	Lymphedema With Distichiasis Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus LPHDST Distichiasis-Lymphedema Syndrome Lymphedema Distichiasis Syndrome Hereditary Lymphedema-Distichiasis Syndrome Lymphedema Distichiasis
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Atrioventricular Septal Defect	AVSD Atrioventricular Canal Defect Avcd Endocardial Cushion Defect Ecd Avc Defect Atrioventricular Septal Defect, Susceptibility To, 1 Atrioventricular Septal Defect 1 Endocardial Cushion Defects Septal Defect, Atrioventricular Atrioventricular Defect With Atrial Shunting Only Incomplete Atrioventricular Septal Defect With Isolated Atrial Component Incomplete Atrioventricular Canal Defect With Isolated Atrial Component Primum Atrial Septal Defect Partial Atrioventricular Canal Defect With Isolated Atrial Component Partial Atrioventricular Septal Defect, Ostium Primum Type Ostium Primum Atrial Septal Defect Partial Atrioventricular Canal Defect Partial Atrioventricular Septal Defect Atrial Septum Primum Defect Atrioventricular Canal Defect With Isolated Ventricular Component Atrioventricular Canal Defect With Isolated Ventricular Communication Atrioventricular Septal Defect With Isolated Ventricular Component Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect Intermediate Atrioventricular Canal Defect Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices Intermediate Atrioventricular Septal Defect Transitional Atrioventricular Canal Defect Transitional Atrioventricular Septal Defect Complete Atrioventricular Canal With Atrial And Ventricular Components Complete Atrioventricular Canal Defect Complete Atrioventricular Septal Defect
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Myopathy	Muscular Diseases Myopathies
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113756A	Latanoprost acid	Agonist	98.77%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16275	Nivocasan	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (38)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0656	Usnic acid		98.90%	Unkown
HY-N0481	Roburic acid		99.93%	Unkown
HY-N0231	Bavachalcone		99.90%	Unkown
HY-N2119	Sciadopitysin	Inhibitor	99.0%	Unkown
HY-B2162B	Chondroitin sulfate sodium (from bovine)	Inhibitor	99.40%	Unkown
HY-147369	NFATc1-IN-1	Inhibitor	99.97%	Unkown
HY-N0616	Trifolirhizin		98.37%	Unkown
HY-N3312	Matairesinol	Inhibitor	98.78%	Unkown
HY-175232	GL64		98.80%	Unkown
HY-N0381	Maackiain		99.83%	Unkown
HY-N5048	Galloylpaeoniflorin	Inhibitor	98.30%	Unkown
HY-N0026	2'-Acetylacteoside	Inhibitor	99.73%	Unkown
HY-N0805A	Alisol B		99.57%	Unkown
HY-W423191	Maltobionic acid	Inhibitor	99.86%	Unkown
HY-15001G	Stemregenin 1 (GMP)	Antagonist	/	Unkown
HY-165126	Schizophyllan		/	Unkown
HY-N2736	3′,4′,7-Trihydroxyflavone	Inhibitor	99.04%	Unkown
HY-N2157	Pteryxin	Inhibitor	99.55%	Unkown
HY-N0853A	Alisol A 24-acetate		98.0%	Unkown
HY-117200	Necrostatin-7	Inhibitor	99.64%	Unkown
HY-182757	Y1693	Inhibitor	99.91%	Unkown
HY-W641445	ELP-004	Inhibitor	99.89%	Unkown
HY-123503	Salicortin	Inhibitor	/	Unkown
HY-124958	NDMC101	Inhibitor	99.91%	Unkown
HY-N2528	Usnic acid sodium	Inhibitor	/	Unkown
HY-107614G	1-Oleoyl lysophosphatidic acid sodium (GMP)	Activator	/	Unkown
HY-113756B	rel-Latanoprost acid	Agonist	/	Unkown
HY-116640	Amorphigenin	Inhibitor	/	Unkown
HY-149852	Anti-osteoporosis agent-3		/	Unkown
HY-162280	PROTAC BTK Degrader-9		/	Unkown
HY-182818	SH494		/	Unkown
HY-N3071	Picrasidine I		/	Unkown
HY-P11617	CLP-d2	Inhibitor	/	Unkown
HY-P4684	Osteostatin		/	Unkown
HY-RS09238	NFATC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W185542	E09241		/	Unkown
HY-RS18427	Nfatc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24908	Nfatc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFATC1	MGD	MGI:102469
Macaca mulatta	NFATC1	VGNC	VGNC:75326
Bos taurus	NFATC1	VGNC	VGNC:32030
Rattus norvegicus	NFATC1	RGD	RGD:2319357
Felis catus	NFATC1	VGNC	VGNC:68469
Canis familiaris	NFATC1	VGNC	VGNC:43766
Others	NFATC1	NCBI