2. Cell Cycle/DNA Damage
  3. CDK
  4. XPW1

XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity.

For research use only. We do not sell to patients.

XPW1 Chemical Structure

XPW1 Chemical Structure

CAS No. : 2700286-66-2

Size Price Stock Quantity
5 mg USD 220 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 1150 In-stock
100 mg USD 1850 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity[1].

Molecular Weight

656.19

Formula

C36H39ClFN7O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N[C@H]1CC[C@H](NC2=NC=C(Cl)C(C3=NC(NCC4=CC=CC(F)=C4)=CC=C3)=C2)CC1)C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (47.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5239 mL 7.6197 mL 15.2395 mL
5 mM 0.3048 mL 1.5239 mL 3.0479 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5239 mL 7.6197 mL 15.2395 mL 38.0987 mL
5 mM 0.3048 mL 1.5239 mL 3.0479 mL 7.6197 mL
10 mM 0.1524 mL 0.7620 mL 1.5239 mL 3.8099 mL
15 mM 0.1016 mL 0.5080 mL 1.0160 mL 2.5399 mL
20 mM 0.0762 mL 0.3810 mL 0.7620 mL 1.9049 mL
25 mM 0.0610 mL 0.3048 mL 0.6096 mL 1.5239 mL
30 mM 0.0508 mL 0.2540 mL 0.5080 mL 1.2700 mL
40 mM 0.0381 mL 0.1905 mL 0.3810 mL 0.9525 mL
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XPW1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XPW12700286-66-2XPW 1XPW-1CDKCyclin dependent kinaseCDK9 inhibitorInhibitorinhibitorinhibit

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