YKL-1-116
Based on 1 Customer Validation
YKL-1-116 is a selective and covalent inhibitor of Cdk7. YKL-1-116 does not target Cdk9, Cdk12, or Cdk13. YKL-1-116 is more potent than THZ1 (HY-80013) toward both Cdk7WT and Cdk7as, although Cdk7as is relatively resistant to this compound as well.
For research use only. We do not sell to patients.
- Purity: 98.67%
- CAS No.: 1957202-71-9
- Formula: C34H38N8O3
- Molecular Weight:606.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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CDK7 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
2 nM
Compound: 27; YKL-1-116
|
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability
|
[PMID: 31514062] |
Chemical Information
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CAS No. 1957202-71-9
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Appearance Solid
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Molecular Weight 606.72
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Formula C34H38N8O3
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Color White to off-white
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SMILES
CC(C)(N(C1)C(N[C@@H](C2=CC=CC=C2)CN(C)C)=O)C3=C1C(NC4=CC(NC(C5=CC=C(C=C5)NC(C=C)=O)=O)=CC=C4)=NN3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)